SCHEMBL7576975

SCHEMBL7576975

CC(c1cn[nH]c1)c1cn(CC(=O)N2CCN(c3ccc(Cl)cn3)CC2)c(SCc2ccc(F)cc2)nc1=O

nearest known ligand 0.57

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
PLA2G7 Q13093 20/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7533118 0.89 PLA2G7 (0.53) PLA2G7
SCHEMBL7564971 0.89 PLA2G7 (0.54) PLA2G7
SCHEMBL7586035 0.89 PLA2G7 (0.62) PLA2G7
SCHEMBL7579290 0.87 PLA2G7 (0.58) PLA2G7
SCHEMBL7596285 0.85 PLA2G7 (0.62) PLA2G7
SCHEMBL7583546 0.84 PLA2G7 (0.64) PLA2G7
SCHEMBL7534683 0.83 PLA2G7 (0.64) PLA2G7
SCHEMBL7586520 0.83 PLA2G7 (0.61) PLA2G7
SCHEMBL7527594 0.80 PLA2G7 (0.51) PLA2G7
SCHEMBL7576977 0.79 PLA2G7 (0.84) PLA2G7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1173424-A1 PYRIMIDINE COMPOUNDS SMITHKLINE BEECHAM PLC (GB) 2002-01-23 EP disclosed
WO-2000066566-A1 PYRIMIDINE COMPOUNDS SMITHKLINE BEECHAM PLC (GB) 2000-11-09 WO disclosed