Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.97 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.97 |
| ▸ | GAA | P10253 | 1/20 | 0.97 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2295833 | 0.87 | ALDH1A1 (0.74) | ALDH1A1SMN1; SMN2GAAEGLN1PKM | |
| SCHEMBL31544568 | 0.86 | ALDH1A1 (0.74) | ALDH1A1SMN1; SMN2GAATP53HTT | |
| SCHEMBL4768446 | 0.86 | ALDH1A1 (0.74) | ALDH1A1SMN1; SMN2GAATP53HTT | |
| Hydrochloric Acid SCHEMBL7110024 | 0.85 | ALDH1A1 (0.77) | ALDH1A1SMN1; SMN2GAAEGLN1PKM | |
| SCHEMBL2553452 | 0.85 | ALDH1A1 (0.72) | ALDH1A1SMN1; SMN2GAATP53EGLN1 | |
| SCHEMBL7108755 | 0.84 | ALDH1A1 (0.71) | ALDH1A1SMN1; SMN2GAAEGLN1PKM | |
| SCHEMBL1514728 | 0.81 | ALDH1A1 (0.66) | ALDH1A1SMN1; SMN2GAATP53EGLN1 | |
| SCHEMBL5717798 | 0.77 | ALDH1A1 (0.61) | ALDH1A1SMN1; SMN2GAAHTTLMNA | |
| SCHEMBL355357 | 0.76 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2GAATP53EGLN1 | |
| SCHEMBL3111830 | 0.76 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2GAAHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036059-B1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2002-09-18 | — | — | EP | disclosed |
| US-6303659-B2 | Compounds | ASTRAZENECA AB (SE) | 2001-10-16 | — | — | US | disclosed |
| US-6258838-B1 | Compounds | ASTRAZENECA AB (SE) | 2001-07-10 | — | — | US | disclosed |
| US-20010003121-A1 | Novel compounds | ASTRAZENECA UK LIMITED | 2001-06-07 | — | — | US | disclosed |
| US-6201024-B1 | EFFECTIVE P2X7 RECEPTOR ANTAGONISTS FOR USE IN THE TREATMENT OF INFLAMMATORY, IMMUNE OR CARDIOVASCULAR DISORDERS | ASTRAZENECA UK LIMITED (GB) | 2001-03-13 | — | — | US | disclosed |
| CN-1284057-A | Adamantane derivatives | ASTRA ZENECA BRITISH LTD (GB) | 2001-02-14 | — | — | CN | disclosed |
| EP-1036059-A1 | ADAMANTANE DERIVATIVES | AstraZeneca UK Limited (GB) | 2000-09-20 | — | — | EP | disclosed |
| WO-1999029661-A1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LIMITED (GB) | 1999-06-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010003121-A1 | Novel compounds | APP, BACE1, CHRNA5 | ALDH1A1 1215/4885SMN1; SMN2 1630/4885GAA 254/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.