Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.55 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | PLCG2 | P16885 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SCD | O00767 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7500740 | 0.84 | SIRT2 (0.40) | NOTUMSIRT2KDM4EPTPN1MCL1 | |
| SCHEMBL8888284 | 0.72 | MCL1 (0.65) | NOTUMMCL1MAPTTSHRNPC1 | |
| SCHEMBL24922864 | 0.72 | NOTUM (0.63) | NOTUMSIRT2MCL1TSHRNPC1 | |
| SCHEMBL5356293 | 0.71 | NOTUM (1.00) | NOTUMSIRT2TSHRNPC1RAB9A | |
| SCHEMBL11759218 | 0.71 | KDM4E (0.35) | KDM4EPLCG2PDE4BPDE4DMAPT | |
| SCHEMBL7491649 | 0.69 | HTT (0.54) | KDM4EPDE4BPDE4DMAPTTSHR | |
| SCHEMBL6041361 | 0.69 | ATM (0.62) | NOTUMMAPTTSHRRAB9A | |
| SCHEMBL1456201 | 0.69 | NOTUM (0.57) | NOTUMF10 | |
| SCHEMBL4068333 | 0.69 | NOTUM (0.57) | NOTUMKDM4ENPC1RAB9AF10 | |
| SCHEMBL5774963 | 0.69 | CYP2A6 (0.38) | KDM4ERAB9AF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1420882-A | Substd. oxoazaheterocyclyl compounds | AVENTIS PHARM PROD INC (US) | 2003-05-28 | — | — | CN | disclosed |
| EP-1208097-A2 | SUBSTITUTED OXOAZAHETEROCYCLYL COMPOUNDS | Aventis Pharmaceuticals Inc. (US) | 2002-05-29 | — | — | EP | disclosed |
| WO-2001007436-A2 | SUBSTITUTED OXOAZAHETEROCYCLYL COMPOUNDS | AVENTIS PHARMACEUTICALS INC. (US) | 2001-02-01 | — | — | WO | disclosed |