Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 6/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | PLCG2 | P16885 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7577573 | 0.84 | NOTUM (0.55) | SIRT2PTPN1NOTUMPDE4BPDE4D | |
| SCHEMBL202064 | 0.72 | RAB9A (0.61) | MAPTNPC1RAB9ASMN1; SMN2MCL1 | |
| SCHEMBL201986 | 0.71 | SIRT2 (0.71) | SIRT2NOTUMNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11759218 | 0.71 | KDM4E (0.35) | PDE4BPDE4DKDM4EMAPTNPC1 | |
| SCHEMBL3369897 | 0.69 | NOTUM (0.38) | NOTUMKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7498466 | 0.69 | KDM4E (0.49) | KDM4EMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8306306 | 0.69 | KDM4E (0.42) | SIRT2PTPN1NOTUMKDM4EMAPT | |
| SCHEMBL220431 | 0.69 | F10 (0.54) | NOTUM | |
| SCHEMBL6041725 | 0.69 | ATM (0.58) | MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30098388 | 0.69 | ATM (0.58) | MAPTNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1208097-A2 | SUBSTITUTED OXOAZAHETEROCYCLYL COMPOUNDS | Aventis Pharmaceuticals Inc. (US) | 2002-05-29 | — | — | EP | disclosed |
| WO-2001007436-A2 | SUBSTITUTED OXOAZAHETEROCYCLYL COMPOUNDS | AVENTIS PHARMACEUTICALS INC. (US) | 2001-02-01 | — | — | WO | disclosed |