SCHEMBL7578086

SCHEMBL7578086

COC(=O)c1ccc(Cl)c(CSC)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 8/20 0.51
TSHR P16473 2/20 0.48
SMN1; SMN2 Q16637 2/20 0.48
CYP1A2 P05177 2/20 0.48
CYP2C19 P33261 2/20 0.48
MAPT P10636 8/20 0.45
L3MBTL1 Q9Y468 3/20 0.45
CA12 O43570 1/20 0.45
CA1 P00915 1/20 0.45
CA2 P00918 1/20 0.45
CA7 P43166 1/20 0.45
XDH P47989 1/20 0.45
CA9 Q16790 1/20 0.45
CA14 Q9ULX7 1/20 0.45
MEN1 O00255 3/20 0.44
KMT2A Q03164 3/20 0.44
KDM4E B2RXH2 3/20 0.44
HPGD P15428 3/20 0.44
LMNA P02545 3/20 0.44
HTT P42858 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4717547 0.82 ALDH1A1 (0.55) ALDH1A1TSHRSMN1; SMN2CYP1A2CYP2C19
SCHEMBL2773973 0.81 PTGDR2 (0.50) ALDH1A1SMN1; SMN2CYP1A2CYP2C19MAPT
SCHEMBL694449 0.81 ALDH1A1 (0.54) ALDH1A1TSHRSMN1; SMN2CYP1A2CYP2C19
SCHEMBL30231055 0.81 ALDH1A1 (0.54) ALDH1A1TSHRSMN1; SMN2CYP1A2CYP2C19
SCHEMBL17522159 0.79 ALDH1A1 (0.56) ALDH1A1TSHRSMN1; SMN2CYP1A2CYP2C19
SCHEMBL29128071 0.79 NPC1 (0.56) ALDH1A1TSHRSMN1; SMN2CYP1A2CYP2C19
SCHEMBL838914 0.79 ALDH1A1 (0.53) ALDH1A1TSHRSMN1; SMN2CYP1A2CYP2C19
SCHEMBL5801989 0.79 ALDH1A1 (0.53) ALDH1A1TSHRSMN1; SMN2CYP1A2CYP2C19
SCHEMBL27341803 0.78 ALDH1A1 (0.51) ALDH1A1TSHRSMN1; SMN2CYP1A2CYP2C19
SCHEMBL4623289 0.78 TSHR (0.54) ALDH1A1TSHRSMN1; SMN2CYP1A2CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0609798-B1 4-Benzoyl isoxazoles and their use as herbicides AVENTIS AGRICULTURE LTD (GB) 2002-10-02 EP disclosed
US-5374606-A Pre- and postemergence RHONE-POULENC AGRICULTURE LIMITED (GB) 1994-12-20 US disclosed
EP-0609798-A1 4-Benzoyl isoxazoles and their use as herbicides RHONE POULENC AGRICULTURE LTD. (GB) 1994-08-10 EP disclosed