Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | LSS | P48449 | 2/20 | 0.41 |
| ▸ | ESR1 | P03372 | 2/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7581397 | 1.00 | THRB (0.52) | THRBHTTALDH1A1TSHRCYP3A4 | |
| SCHEMBL7573889 | 1.00 | THRB (0.52) | THRBHTTALDH1A1TSHRCYP3A4 | |
| SCHEMBL7573086 | 1.00 | THRB (0.52) | THRBHTTALDH1A1TSHRCYP3A4 | |
| SCHEMBL7573309 | 1.00 | THRB (0.52) | THRBHTTALDH1A1TSHRCYP3A4 | |
| SCHEMBL7573088 | 1.00 | THRB (0.52) | THRBHTTALDH1A1TSHRCYP3A4 | |
| SCHEMBL7573281 | 1.00 | THRB (0.52) | THRBHTTALDH1A1TSHRCYP3A4 | |
| SCHEMBL7575091 | 1.00 | THRB (0.52) | THRBHTTALDH1A1TSHRCYP3A4 | |
| SCHEMBL7573084 | 0.99 | THRB (0.53) | THRBHTTALDH1A1TSHRCYP3A4 | |
| SCHEMBL7578974 | 0.96 | THRB (0.53) | THRBHTTALDH1A1TSHRCYP3A4 | |
| SCHEMBL7575073 | 0.95 | THRB (0.49) | THRBHTTALDH1A1TSHRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0731084-B1 | Photocrosslinkable naphthyl derivatives | ROLIC AG (CH) | 2002-09-25 | — | — | EP | disclosed |
| US-5851427-A | Photocross-linkable naphthyl derivatives | ROLIC AG (CH) | 1998-12-22 | — | — | US | disclosed |
| EP-0731084-A2 | Photocrosslinkable naphthyl derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1996-09-11 | — | — | EP | disclosed |