Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7526964 | 0.91 | ALDH1A1 (0.39) | ALDH1A1LMNAKMT2AHSD17B10MEN1 | |
| SCHEMBL2532522 | 0.91 | ALDH1A1 (0.39) | ALDH1A1LMNAKMT2AHSD17B10MEN1 | |
| SCHEMBL344909 | 0.91 | ALDH1A1 (0.39) | ALDH1A1LMNAKMT2AHSD17B10MEN1 | |
| SCHEMBL2528683 | 0.91 | ALDH1A1 (0.39) | ALDH1A1LMNAKMT2AHSD17B10MEN1 | |
| Glycerin SCHEMBL8149757 | 0.89 | USP2 (0.41) | TDP1USP2ALDH1A1LMNAKMT2A | |
| SCHEMBL1002493 | 0.89 | ALDH1A1 (0.38) | ALDH1A1LMNAKMT2AHSD17B10MEN1 | |
| SCHEMBL195733 | 0.89 | — | — | |
| SCHEMBL17800988 | 0.86 | ALDH1A1 (0.36) | ALDH1A1LMNAKMT2AHSD17B10MEN1 | |
| SCHEMBL8782077 | 0.86 | ALDH1A1 (0.38) | ALDH1A1LMNAKMT2AHSD17B10MEN1 | |
| Propylene Glycol SCHEMBL27888491 | 0.83 | USP2 (0.47) | TDP1USP2ALDH1A1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237532-A2 | ULTRAVIOLET RADIATION ABSORBING WAXES USEFUL IN COSMETIC COMPOSITIONS | The C.P. Hall Company (US) | 2002-09-11 | — | — | EP | disclosed |
| WO-2001041715-A2 | ULTRAVIOLET RADIATION ABSORBING WAXES USEFUL IN COSMETIC COMPOSITIONS | THE C.P. HALL COMPANY (US) | 2001-06-14 | — | — | WO | disclosed |