Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | FNTA | P49354 | 1/20 | 0.44 |
| ▸ | FNTB | P49356 | 1/20 | 0.44 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.44 |
| ▸ | ANPEP | P15144 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5869294 | 1.00 | BACE1 (0.47) | BACE1PLK1CASP1HDAC8SMN1; SMN2 | |
| SCHEMBL5869282 | 1.00 | BACE1 (0.47) | BACE1PLK1CASP1HDAC8SMN1; SMN2 | |
| SCHEMBL5869277 | 1.00 | BACE1 (0.47) | BACE1PLK1CASP1HDAC8SMN1; SMN2 | |
| SCHEMBL5869651 | 0.88 | HPGD (0.48) | BACE1PLK1CASP1HDAC8SMN1; SMN2 | |
| SCHEMBL5869668 | 0.88 | HPGD (0.48) | BACE1PLK1CASP1HDAC8SMN1; SMN2 | |
| SCHEMBL5869660 | 0.88 | HPGD (0.48) | BACE1PLK1CASP1HDAC8SMN1; SMN2 | |
| SCHEMBL8255635 | 0.85 | PLK1 (0.47) | PLK1HDAC8SMN1; SMN2MMP3MEN1 | |
| SCHEMBL6244622 | 0.83 | CASP1 (0.57) | BACE1PLK1CASP1FNTAFNTB | |
| SCHEMBL6244616 | 0.83 | CASP1 (0.57) | BACE1PLK1CASP1FNTAFNTB | |
| SCHEMBL16866255 | 0.81 | PLK1 (0.60) | BACE1PLK1HDAC8SMN1; SMN2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | disclosed |