Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.36 |
| ▸ | MC4R | P32245 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14559834 | 0.73 | ALDH1A1 (0.38) | KMT2ALMNAALDH1A1GAA | |
| SCHEMBL13892809 | 0.71 | ALDH1A1 (0.49) | KMT2ALMNAALDH1A1GAA | |
| SCHEMBL7116479 | 0.70 | KMT2A (0.47) | KMT2ALMNAALDH1A1MEN1GAA | |
| SCHEMBL1274762 | 0.70 | ALDH1A1 (0.56) | KMT2ALMNAALDH1A1MEN1GAA | |
| SCHEMBL30059683 | 0.70 | ALDH1A1 (0.56) | KMT2ALMNAALDH1A1MEN1GAA | |
| SCHEMBL23879259 | 0.70 | GAA (0.43) | KMT2ALMNAALDH1A1GAA | |
| SCHEMBL16111406 | 0.70 | HDAC4 (0.48) | KMT2AALDH1A1HDAC4HDAC3HDAC7 | |
| SCHEMBL5402848 | 0.70 | GAA (0.50) | KMT2ALMNAALDH1A1GAA | |
| SCHEMBL30452188 | 0.70 | GAA (0.43) | KMT2ALMNAALDH1A1GAA | |
| SCHEMBL4013185 | 0.69 | MAPK13 (0.39) | KMT2AALDH1A1HDAC4HDAC3HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0810218-B1 | 6-Benzyl-2H-pyridazin-3-one derivatives,their preparation and their use as inhibitors of prostaglandin G/H synthase I and II (COX I and COX II) | HOFFMANN LA ROCHE (CH) | 2002-12-04 | — | — | EP | disclosed |
| US-5886178-A | ADMINISTERING OF A PROSTAGLANDIN G/H SYNTHASE INHIBITOR TO A PATIENT TO TREAT INFLAMMATORY OR AUTOIMMUNE DISEASES | SYNTEX (U.S.A.) INC. (US) | 1999-03-23 | — | — | US | disclosed |
| EP-0810218-A1 | 6-Benzyl-2H-pyridazin-3-one derivatives,their preparation and their use as inhibitors of prostaglandin G/H synthase I and II (COX I and COX II) | F. HOFFMANN-LA ROCHE AG (CH) | 1997-12-03 | — | — | EP | disclosed |