Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 15/20 | 0.53 |
| ▸ | QPCT | Q16769 | 8/20 | 0.53 |
| ▸ | PRKCA | P17252 | 5/20 | 0.53 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.50 |
| ▸ | IDH1 | O75874 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7531023 | 0.87 | CDK2 (0.62) | GSK3BIDH1 | |
| SCHEMBL7524890 | 0.86 | GSK3B (0.56) | GSK3BQPCTIDH1 | |
| SCHEMBL7499657 | 0.84 | GSK3B (0.70) | GSK3BPRKCA | |
| SCHEMBL7530543 | 0.83 | GSK3B (0.45) | GSK3BQPCTIDH1 | |
| SCHEMBL7990667 | 0.82 | GSK3B (0.45) | GSK3BQPCTIDH1 | |
| SCHEMBL7990678 | 0.79 | GSK3B (0.59) | GSK3BPRKCA | |
| SCHEMBL7501398 | 0.78 | GSK3B (0.79) | GSK3BQPCTPRKCA | |
| SCHEMBL8155150 | 0.78 | PRKCA (0.80) | GSK3BPRKCA | |
| SCHEMBL7501399 | 0.78 | GSK3B (0.59) | GSK3BPRKCA | |
| SCHEMBL7498988 | 0.77 | GSK3B (0.61) | GSK3BPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6281356-B1 | ANTICANRCER AGENTS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | claimed |
| EP-1242409-A2 | SUBSTITUTED BISINDOLYLMALEIMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-09-25 | — | — | EP | disclosed |
| US-6281356-B1 | ANTICANRCER AGENTS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |
| WO-2001046178-A2 | SUBSTITUIERTE BISINDOLYMALEIMIDE | F. HOFFMANN-LA ROCHE AG (CH) | 2001-06-28 | — | — | WO | disclosed |