Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 14/20 | 0.58 |
| ▸ | KDR | P35968 | 6/20 | 0.58 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4045059 | 0.90 | KDR (0.72) | MAPK14KDR | |
| SCHEMBL27888123 | 0.89 | EGFR (0.56) | MAPK14KDREGFR | |
| SCHEMBL5739243 | 0.86 | KDR (0.60) | MAPK14KDREGFR | |
| SCHEMBL14451947 | 0.84 | MAPK14 (0.51) | MAPK14KDREGFR | |
| SCHEMBL5516114 | 0.83 | KDR (0.80) | KDREGFR | |
| SCHEMBL5740421 | 0.83 | KDR (0.52) | MAPK14KDREGFR | |
| SCHEMBL4044821 | 0.83 | MAPK14 (0.69) | MAPK14KDR | |
| SCHEMBL27582132 | 0.83 | MAPK14 (0.59) | MAPK14KDR | |
| SCHEMBL4044344 | 0.81 | EGFR (0.66) | MAPK14KDREGFR | |
| SCHEMBL7530745 | 0.81 | KDR (0.70) | MAPK14KDREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1622946-A | Methods of treating conditions associated with p38 kinase and pyrrolotriazine compounds useful as kinase inhibitors | BRISTOL MYERS SQUIBB CO (US) | 2005-06-01 | — | — | CN | disclosed |
| EP-1183033-A4 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL MYERS SQUIBB CO (US) | 2002-07-17 | — | — | EP | disclosed |
| EP-1183033-A1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000071129-A1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-11-30 | — | — | WO | disclosed |