Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
| ▸ | PSEN1 | P49768 | 8/20 | 0.50 |
| ▸ | PSEN2 | P49810 | 8/20 | 0.50 |
| ▸ | APH1B | Q8WW43 | 8/20 | 0.50 |
| ▸ | NCSTN | Q92542 | 8/20 | 0.50 |
| ▸ | APH1A | Q96BI3 | 8/20 | 0.50 |
| ▸ | PSENEN | Q9NZ42 | 8/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | HPGDS | O60760 | 1/20 | 0.47 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | WDR5 | P61964 | 2/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL757612 | 0.85 | PSEN1 (0.57) | PDE4APDE4BPDE4CPDE4DPSEN1 | |
| SCHEMBL6853438 | 0.84 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DPSEN1 | |
| SCHEMBL761019 | 0.80 | PSEN1 (0.50) | PDE4APDE4BPDE4CPDE4DPSEN1 | |
| SCHEMBL5273125 | 0.79 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DROCK2 | |
| SCHEMBL5277673 | 0.79 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DROCK2 | |
| SCHEMBL31157569 | 0.79 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DROCK2 | |
| SCHEMBL760378 | 0.79 | PSEN1 (0.57) | PDE4APDE4BPDE4CPDE4DPSEN1 | |
| SCHEMBL6852850 | 0.78 | PSEN1 (0.58) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1239307 | 0.77 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DPSEN1 | |
| SCHEMBL1239305 | 0.77 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DPSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120053165-A1 | Novel Phenyl Imidazoles and Phenyl Triazoles As Gamma-Secretase Modulators | PFIZER INC. (US) | 2012-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120053165-A1 | Novel Phenyl Imidazoles and Phenyl Triazoles As Gamma-Secretase Modulators | BACE1, BACE2, PSEN1 | PDE4A 622/4885PDE4B 388/4885PDE4C 1070/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.