Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.58 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.58 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.55 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.54 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.54 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.54 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.54 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.54 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL761019 | 0.87 | PSEN1 (0.50) | PDE4APDE4BPDE4CPDE4DTAS1R3 | |
| SCHEMBL758318 | 0.84 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL757612 | 0.83 | PSEN1 (0.57) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL1239308 | 0.82 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL1239307 | 0.82 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL1239305 | 0.82 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL12993297 | 0.82 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL760378 | 0.82 | PSEN1 (0.57) | PDE4APDE4BPDE4CPDE4DPSEN1 | |
| SCHEMBL12739133 | 0.81 | PSEN1 (0.59) | KMT2AMEN1LMNAPSEN1PSEN2 | |
| SCHEMBL5923942 | 0.79 | TAS1R3 (0.74) | PDE4APDE4BPDE4CPDE4DPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011059048-A1 | NOVEL AMIDE DERIVATIVE | 大日本住友製薬株式会社 (JP) | 2011-05-19 | — | — | WO | disclosed |