Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 7/20 | 0.38 |
| ▸ | CNR1 | P21554 | 5/20 | 0.38 |
| ▸ | DRD2 | P14416 | 5/20 | 0.38 |
| ▸ | DRD3 | P35462 | 5/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7585656 | 0.91 | CHRNA7 (0.43) | CHRNA7MEN1KMT2ACNR2CNR1 | |
| SCHEMBL7585930 | 0.90 | CHRNA7 (0.40) | CHRNA7KMT2ACNR2CNR1DRD2 | |
| SCHEMBL7582940 | 0.90 | CYP1A2 (0.40) | DRD2DRD3HTR2AALDH1A1LMNA | |
| SCHEMBL7583632 | 0.83 | CHRNA7 (0.43) | CHRNA7MEN1KMT2ACNR2CNR1 | |
| SCHEMBL7585162 | 0.81 | CHRNA7 (0.42) | CHRNA7MEN1KMT2ACNR2CNR1 | |
| SCHEMBL7583559 | 0.81 | CYP1A2 (0.41) | CNR2DRD2DRD3HTR2AALDH1A1 | |
| SCHEMBL7583679 | 0.81 | DRD2 (0.44) | DRD2DRD3KDM4EALDH1A1LMNA | |
| SCHEMBL7582663 | 0.80 | CHRNA7 (0.41) | CHRNA7MEN1KMT2ADRD2DRD3 | |
| SCHEMBL7583647 | 0.80 | TACR1 (0.38) | MEN1KMT2ADRD2DRD3HTR2A | |
| SCHEMBL7581273 | 0.80 | CHRNA7 (0.36) | CHRNA7MEN1KMT2ACNR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | claimed |
| EP-0675118-A2 | Biphenylderivatives, process for their preparation and their use as medicaments | Eisai Co., Ltd. (JP) | 1995-10-04 | — | — | EP | claimed |
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | disclosed |
| US-6281214-B1 | USEFUL FOR TREATING AND AMELIORATING MENTAL DISORDERS | EISAI CO., LTD (JP) | 2001-08-28 | — | — | US | disclosed |
| EP-0675118-A2 | Biphenylderivatives, process for their preparation and their use as medicaments | Eisai Co., Ltd. (JP) | 1995-10-04 | — | — | EP | disclosed |