Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7031855 | 0.84 | TSHR (0.49) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL11293409 | 0.84 | TSHR (0.36) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL1563224 | 0.83 | TSHR (0.50) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL14523947 | 0.81 | TSHR (0.49) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL7609199 | 0.81 | TSHR (0.49) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL1772849 | 0.80 | TSHR (0.55) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL14525085 | 0.79 | TSHR (0.44) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL3597832 | 0.79 | TSHR (0.49) | TSHRTHRBALDH1A1 | |
| SCHEMBL960508 | 0.78 | — | — | |
| SCHEMBL9358119 | 0.78 | TSHR (0.45) | TSHRTHRBPOLBAPEX1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0455585-B1 | Unsaturated urea polysiloxanes | CIBA GEIGY AG (CH) | 1994-03-23 | — | — | EP | claimed |
| US-5106930-A | Copolymer of polysiloxanylalkyl ester of acrylic acid, fluorinated styrene | IOPTEX RESEARCH INC. (US) | 1992-04-21 | — | — | US | claimed |
| EP-0455585-A1 | Unsaturated urea polysiloxanes | CIBA-GEIGY AG (CH) | 1991-11-06 | — | — | EP | claimed |
| EP-0296220-A4 | WETTABLE, HYDROPHILIC, SOFT AND OXYGEN PERMEABLE COPOLYMER COMPOSITIONS. | CHANG SING-HSIUNG (US) | 1989-05-11 | — | — | EP | claimed |
| EP-0296220-A1 | WETTABLE, HYDROPHILIC, SOFT AND OXYGEN PERMEABLE COPOLYMER COMPOSITIONS | CHANG, Sing-Hsiung (US) | 1988-12-28 | — | — | EP | claimed |
| WO-1988005060-A1 | WETTABLE, HYDROPHILIC, SOFT AND OXYGEN PERMEABLE COPOLYMER COMPOSITIONS | CHANG SING HSIUNG (US) | 1988-07-14 | — | — | WO | claimed |
| EP-0108886-A2 | Silicone-containing hard contact lens materials having increased oxygen permeability | CIBA-GEIGY AG (CH) | 1984-05-23 | — | — | EP | claimed |
| EP-0670770-B1 | METHODS OF MANUFACTURING A CONTACT LENS | JESSEN WESLEY CORP (US) | 2002-10-09 | — | — | EP | disclosed |
| US-5770669-A | Silcone-containing polymer having oxygen permeability suitable for ophalmic applications | CIBA VISION CORPORATION (US) | 1998-06-23 | — | — | US | disclosed |
| EP-0796448-A1 | SILICONE-CONTAINING POLYMER SUITABLE FOR OPHTHALMIC APPLICATIONS | Novartis AG (CH) | 1997-09-24 | — | — | EP | disclosed |
| WO-1996018122-A1 | SILICONE-CONTAINING POLYMER SUITABLE FOR OPHTHALMIC APPLICATIONS | NOVARTIS AG (CH) | 1996-06-13 | — | — | WO | disclosed |
| US-5480946-A | CONTACT LENSES | CIBA GEIGY CORPORATION (US) | 1996-01-02 | — | — | US | disclosed |
| US-5364918-A | Surface modification of polymer objects | BAUSCH & LOMB INCORPORATED (US) | 1994-11-15 | — | — | US | disclosed |
| US-4837289-A | CONTACT LENSES | CIBA-GEIGY CORPORATION (US) | 1989-06-06 | — | — | US | disclosed |
| EP-0296220-A4 | WETTABLE, HYDROPHILIC, SOFT AND OXYGEN PERMEABLE COPOLYMER COMPOSITIONS. | CHANG SING-HSIUNG (US) | 1989-05-11 | — | — | EP | disclosed |
| EP-0311566-A2 | Thermotropic biphilic hydrogels and hydroplastics | CIBA-GEIGY AG (CH) | 1989-04-12 | — | — | EP | disclosed |
| EP-0296220-A1 | WETTABLE, HYDROPHILIC, SOFT AND OXYGEN PERMEABLE COPOLYMER COMPOSITIONS | CHANG, Sing-Hsiung (US) | 1988-12-28 | — | — | EP | disclosed |
| EP-0291452-A2 | Terminal polyvinyl functional macromers, polymers thereof and contact lenses made therefrom | CIBA-GEIGY AG (CH) | 1988-11-17 | — | — | EP | disclosed |
| WO-1988005060-A1 | WETTABLE, HYDROPHILIC, SOFT AND OXYGEN PERMEABLE COPOLYMER COMPOSITIONS | CHANG SING HSIUNG (US) | 1988-07-14 | — | — | WO | disclosed |
| EP-0108886-A2 | Silicone-containing hard contact lens materials having increased oxygen permeability | CIBA-GEIGY AG (CH) | 1984-05-23 | — | — | EP | disclosed |