Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.49 |
| ▸ | HTR2A | P28223 | 4/20 | 0.46 |
| ▸ | HTR2C | P28335 | 4/20 | 0.46 |
| ▸ | HTR2B | P41595 | 2/20 | 0.46 |
| ▸ | TNKS | O95271 | 5/20 | 0.43 |
| ▸ | TNKS2 | Q9H2K2 | 4/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.37 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6841463 | 0.89 | SIGMAR1 (0.60) | DRD2SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL6841136 | 0.87 | SIGMAR1 (0.50) | DRD2SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL6841620 | 0.85 | SIGMAR1 (0.64) | DRD2SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL6841619 | 0.84 | SIGMAR1 (0.69) | DRD2SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL6840788 | 0.81 | SIGMAR1 (0.60) | DRD2SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL6840779 | 0.77 | SIGMAR1 (0.64) | DRD2SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL6843241 | 0.76 | SIGMAR1 (0.69) | DRD2SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL6836319 | 0.76 | SIGMAR1 (0.55) | DRD2SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL6841677 | 0.74 | SIGMAR1 (0.62) | DRD2SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL6836344 | 0.74 | SIGMAR1 (0.64) | DRD2SIGMAR1HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1235808-A2 | TRICYCLIC ANALGESICS | WARNER-LAMBERT COMPANY (US) | 2002-09-04 | — | — | EP | disclosed |
| WO-2000075116-A2 | TRICYCLIC ANALGESICS | WARNER-LAMBERT COMPANY (US) | 2000-12-14 | — | — | WO | disclosed |