⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrahydrofuran SCHEMBL6904731 | 0.85 | — | — | |
| Magnesium Chloride Anhydrous SCHEMBL20447687 | 0.81 | — | — | |
| Tetrahydrofuran SCHEMBL29225232 | 0.81 | — | — | |
| Tetrahydrofuran SCHEMBL28306631 | 0.80 | — | — | |
| Tetrahydrofuran SCHEMBL28246844 | 0.79 | ALDH1A1 (0.57) | — | |
| Tetrahydrofuran SCHEMBL3049680 | 0.79 | — | — | |
| Tetrahydrofuran SCHEMBL28572801 | 0.79 | — | — | |
| Tetrahydrofuran SCHEMBL28415745 | 0.78 | ALDH1A1 (0.47) | — | |
| Tetrahydrofuran SCHEMBL1821838 | 0.78 | ALDH1A1 (0.47) | — | |
| Chloromethane SCHEMBL27584162 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022252789-A1 | METHOD FOR PREPARING JAK INHIBITOR KEY INTERMEDIATE | 山东莱福科技发展有限公司 | 2022-12-08 | — | — | WO | claimed |
| WO-2022252789-A1 | METHOD FOR PREPARING JAK INHIBITOR KEY INTERMEDIATE | 山东莱福科技发展有限公司 | 2022-12-08 | — | — | WO | disclosed |
| CN-113336761-B | Preparation method of JAK inhibitor key intermediate | 山东莱福科技发展有限公司 | 2022-07-29 | — | — | CN | disclosed |
| US-20210363110-A1 | 4-METHYLDIHYDROPYRIMIDINONE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2021-11-25 | — | — | US | disclosed |
| CN-108175749-B | Melt-extruded solid dispersions containing apoptosis-inducing agents | 艾伯维爱尔兰无限公司 | 2021-09-10 | — | — | CN | disclosed |
| CN-113336761-A | Preparation method of JAK inhibitor key intermediate | 山东莱福科技发展有限公司 | 2021-09-03 | — | — | CN | disclosed |
| US-10899717-B2 | 4-methyldihydropyrimidinone compounds and pharmaceutical use thereof | JAPAN TOBACCO INC. (JP) | 2021-01-26 | — | — | US | disclosed |
| EP-3760616-A1 | 4-METHYLDIHYDROPYRIMIDINONE COMPOUND AND MEDICINAL USE THEREOF | Japan Tobacco Inc. (JP) | 2021-01-06 | — | — | EP | disclosed |
| CN-111741947-A | 4-methyl dihydropyrimidinone compound and pharmaceutical use thereof | 日本烟草产业株式会社 | 2020-10-02 | — | — | CN | disclosed |
| EP-3360869-B1 | HALOGEN-SUBSTITUTED HETEROCYCLIC COMPOUND USEFUL FOR THE TREATMENT OF DISEASES CAUSED BY LPA. | UBE INDUSTRIES (JP) | 2020-07-29 | — | — | EP | disclosed |
| US-8598292-B2 | Adamantane derivative, method for producing same, polymer using same as starting material, and resin composition | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2013-12-03 | — | — | US | disclosed |
| US-20110319584-A1 | ADAMANTANE DERIVATIVE, METHOD FOR PRODUCING SAME, POLYMER USING SAME AS STARTING MATERIAL, AND RESIN COMPOSITION | MITSUBISHI GAS CHEMICAL COMPANY, INC (JP) | 2011-12-29 | — | — | US | disclosed |
| US-6476056-B2 | ANTIINFLAMMATORY AGENTS, PSYCHOLOGICAL DISORDERS | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2002-11-05 | — | — | US | disclosed |
| EP-1004573-B1 | ARYLOXYANILINE DERIVATIVES | TAISHO PHARMACEUTICAL CO LTD (JP) | 2002-10-30 | — | — | EP | disclosed |
| US-20020147191-A1 | Aryloxyaniline derivatives | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2002-10-10 | — | — | US | disclosed |
| US-6333358-B1 | AMIDE DERIVATIVES OF ANILINE AS ANTIDEPRESSANTS | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2001-12-25 | — | — | US | disclosed |
| EP-1004573-A1 | ARYLOXYANILINE DERIVATIVES | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2000-05-31 | — | — | EP | disclosed |
| EP-0178633-B1 | 2-phenylpyrano[2,3-b]pyridines | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-01-08 | — | — | EP | disclosed |
| US-4588733-A | 2-phenylpyrano[2,3-b]pyridines and their use in inhibiting viruses | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-05-13 | — | — | US | disclosed |
| EP-0178633-A2 | 2-phenylpyrano[2,3-b]pyridines | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-04-23 | — | — | EP | disclosed |