Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.42 |
| ▸ | PLK4 | O00444 | 2/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.31 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.31 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.31 |
| ▸ | PAK4 | O96013 | 2/20 | 0.31 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.31 |
| ▸ | PRKCG | P05129 | 2/20 | 0.31 |
| ▸ | CDK1 | P06493 | 2/20 | 0.31 |
| ▸ | PRKACA | P17612 | 2/20 | 0.31 |
| ▸ | CDK2 | P24941 | 2/20 | 0.31 |
| ▸ | MARK3 | P27448 | 2/20 | 0.31 |
| ▸ | AKT1 | P31749 | 2/20 | 0.31 |
| ▸ | AKT2 | P31751 | 2/20 | 0.31 |
| ▸ | FLT4 | P35916 | 2/20 | 0.31 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.31 |
| ▸ | GSK3A | P49840 | 2/20 | 0.31 |
| ▸ | GSK3B | P49841 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL758641 | 1.00 | MAPKAPK2 (0.42) | MAPKAPK2PLK4CHEK1MAPK13PDPK1 | |
| SCHEMBL10214599 | 1.00 | MAPKAPK2 (0.42) | MAPKAPK2PLK4CHEK1MAPK13PDPK1 | |
| SCHEMBL760565 | 0.86 | MAPKAPK2 (0.58) | MAPKAPK2PLK4CHEK1MAPK13PDPK1 | |
| SCHEMBL757768 | 0.86 | MAPKAPK2 (0.45) | MAPKAPK2PLK4CHEK1MAPK13PDPK1 | |
| SCHEMBL757767 | 0.86 | MAPKAPK2 (0.45) | MAPKAPK2PLK4CHEK1MAPK13PDPK1 | |
| SCHEMBL759176 | 0.85 | MAPKAPK2 (0.43) | MAPKAPK2PLK4CHEK1MAPK13PDPK1 | |
| SCHEMBL759863 | 0.82 | MAPKAPK2 (0.42) | MAPKAPK2PLK4CHEK1MAPK13PDPK1 | |
| SCHEMBL759864 | 0.82 | MAPKAPK2 (0.42) | MAPKAPK2PLK4CHEK1MAPK13PDPK1 | |
| SCHEMBL10213788 | 0.80 | MAPKAPK2 (0.36) | MAPKAPK2PLK4CHEK1MAPK13PDPK1 | |
| SCHEMBL759991 | 0.80 | MAPKAPK2 (0.38) | MAPKAPK2PLK4CHEK1MAPK13PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120053345-A1 | Indazole Compounds | ABBOTT LABORATORIES (US) | 2012-03-01 | — | — | US | disclosed |
| US-8008481-B2 | Indazole compounds | ABBVIE INC. | 2011-08-30 | — | — | US | disclosed |
| US-20070282101-A1 | Indazole compounds | ABBVIE INC. | 2007-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070282101-A1 | Indazole compounds | CYP3A43, CYP3A7, UGT1A1 | MAPKAPK2 1905/4885PLK4 1716/4885CHEK1 1404/4885 |
| US-20120053345-A1 | Indazole Compounds | CYP3A43, CYP3A7, UGT1A1 | MAPKAPK2 1905/4885PLK4 1716/4885CHEK1 1404/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.