Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 14/20 | 0.69 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.52 |
| ▸ | TMPRSS11D | O60235 | 7/20 | 0.52 |
| ▸ | F10 | P00742 | 1/20 | 0.51 |
| ▸ | PLG | P00747 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7589201 | 0.90 | F2 (0.70) | F2PRSS1 | |
| Hydrochloric Acid SCHEMBL15251679 | 0.90 | F2 (0.60) | F2PRSS1TMPRSS11DF10PLG | |
| SCHEMBL9087480 | 0.90 | TMPRSS11D (0.57) | F2PRSS1TMPRSS11DF10PLG | |
| SCHEMBL7341166 | 0.88 | F2 (0.53) | F2PRSS1TMPRSS11DF10PLG | |
| SCHEMBL7341151 | 0.88 | TMPRSS11D (0.57) | F2PRSS1TMPRSS11DF10PLG | |
| SCHEMBL7585036 | 0.86 | F2 (0.75) | F2PRSS1 | |
| SCHEMBL13061899 | 0.86 | F2 (0.75) | F2PRSS1 | |
| SCHEMBL9085053 | 0.86 | TMPRSS11D (0.52) | F2PRSS1TMPRSS11DF10PLG | |
| SCHEMBL9085068 | 0.85 | F2 (0.50) | F2PRSS1TMPRSS11DF10PLG | |
| SCHEMBL9088895 | 0.84 | STS (0.54) | F2TMPRSS11DF10PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772590-B1 | THROMBIN INHIBITORS | MERCK & CO INC (US) | 2002-10-09 | — | — | EP | disclosed |
| US-5714485-A | Piperidine and hexahydropyridazine thrombin inhibitors | MERCK & CO., INC. (US) | 1998-02-03 | — | — | US | disclosed |
| US-5510369-A | ANTICOAGULANTS | MERCK & CO., INC. (US) | 1996-04-23 | — | — | US | disclosed |