Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 10/20 | 0.78 |
| ▸ | NOD2 | Q9HC29 | 10/20 | 0.78 |
| ▸ | ACVR1 | Q04771 | 7/20 | 0.78 |
| ▸ | WEE1 | P30291 | 6/20 | 0.61 |
| ▸ | SRC | P12931 | 6/20 | 0.61 |
| ▸ | BTK | Q06187 | 2/20 | 0.60 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.60 |
| ▸ | JAK2 | O60674 | 1/20 | 0.60 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.60 |
| ▸ | PAK4 | O96013 | 1/20 | 0.60 |
| ▸ | ABL1 | P00519 | 1/20 | 0.60 |
| ▸ | EGFR | P00533 | 1/20 | 0.60 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.60 |
| ▸ | LCK | P06239 | 1/20 | 0.60 |
| ▸ | FYN | P06241 | 1/20 | 0.60 |
| ▸ | CSF1R | P07333 | 1/20 | 0.60 |
| ▸ | RET | P07949 | 1/20 | 0.60 |
| ▸ | IGF1R | P08069 | 1/20 | 0.60 |
| ▸ | MET | P08581 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20563994 | 0.88 | RIPK2 (1.00) | RIPK2NOD2ACVR1WEE1SRC | |
| SCHEMBL7586069 | 0.87 | FGFR1 (0.79) | RIPK2NOD2ACVR1WEE1SRC | |
| SCHEMBL4679629 | 0.82 | RIPK2 (0.66) | RIPK2NOD2ACVR1WEE1SRC | |
| SCHEMBL5520426 | 0.81 | RIPK2 (0.73) | RIPK2NOD2ACVR1WEE1SRC | |
| SCHEMBL20563559 | 0.80 | RIPK2 (1.00) | RIPK2NOD2ACVR1WEE1SRC | |
| SCHEMBL20564685 | 0.80 | RIPK2 (1.00) | RIPK2NOD2ACVR1WEE1SRC | |
| SCHEMBL29498196 | 0.79 | RIPK2 (1.00) | RIPK2NOD2ACVR1WEE1SRC | |
| SCHEMBL20564638 | 0.79 | RIPK2 (1.00) | RIPK2NOD2ACVR1WEE1SRC | |
| SCHEMBL20564349 | 0.79 | RIPK2 (1.00) | RIPK2NOD2ACVR1WEE1SRC | |
| SCHEMBL29498217 | 0.79 | RIPK2 (1.00) | RIPK2NOD2ACVR1WEE1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002076396-A2 | COMPOUNDS USEFUL AS KINASE INHIBITORS FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 2002-10-03 | — | — | WO | claimed |