Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 10/20 | 0.79 |
| ▸ | SRC | P12931 | 8/20 | 0.79 |
| ▸ | RIPK2 | O43353 | 6/20 | 0.79 |
| ▸ | NOD2 | Q9HC29 | 6/20 | 0.79 |
| ▸ | ACVR1 | Q04771 | 5/20 | 0.79 |
| ▸ | WEE1 | P30291 | 5/20 | 0.79 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.79 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.79 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.79 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.79 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.79 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.79 |
| ▸ | JAK2 | O60674 | 1/20 | 0.79 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.79 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.79 |
| ▸ | PAK4 | O96013 | 1/20 | 0.79 |
| ▸ | ABL1 | P00519 | 1/20 | 0.79 |
| ▸ | EGFR | P00533 | 1/20 | 0.79 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.79 |
| ▸ | LCK | P06239 | 1/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pd-0166285 SCHEMBL133914 | 0.88 | FGFR1 (1.00) | FGFR1SRCRIPK2NOD2ACVR1 | |
| Pd-0166285 SCHEMBL30250248 | 0.88 | FGFR1 (1.00) | FGFR1SRCRIPK2NOD2ACVR1 | |
| Pd-0166285 SCHEMBL30276696 | 0.87 | FGFR1 (0.98) | FGFR1SRCRIPK2NOD2ACVR1 | |
| Pd-0166285 SCHEMBL15106017 | 0.87 | FGFR1 (0.98) | FGFR1SRCRIPK2NOD2ACVR1 | |
| SCHEMBL7586440 | 0.87 | RIPK2 (0.78) | FGFR1SRCRIPK2NOD2ACVR1 | |
| Pd-0166285 SCHEMBL15923205 | 0.87 | FGFR1 (0.97) | FGFR1SRCRIPK2NOD2ACVR1 | |
| Pd-0166285 SCHEMBL29658286 | 0.87 | FGFR1 (0.97) | FGFR1SRCRIPK2NOD2ACVR1 | |
| SCHEMBL7570414 | 0.85 | SRC (0.76) | FGFR1SRCRIPK2NOD2ACVR1 | |
| SCHEMBL7588184 | 0.84 | SRC (0.61) | FGFR1SRCRIPK2NOD2ACVR1 | |
| SCHEMBL10108147 | 0.84 | FGFR1 (0.91) | FGFR1SRCRIPK2NOD2ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002076396-A2 | COMPOUNDS USEFUL AS KINASE INHIBITORS FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 2002-10-03 | — | — | WO | claimed |
| WO-2002076396-A2 | COMPOUNDS USEFUL AS KINASE INHIBITORS FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 2002-10-03 | — | — | WO | disclosed |