Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | SHBG | P04278 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
| ▸ | ACACB | O00763 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7178856 | 0.78 | SHBG (0.42) | NPC1MAPTRAB9ASMN1; SMN2CYP3A4 | |
| SCHEMBL7904973 | 0.78 | SMN1; SMN2 (0.44) | NPC1MAPTRAB9ASMN1; SMN2CYP3A4 | |
| SCHEMBL30407868 | 0.73 | CA1 (0.39) | — | |
| SCHEMBL11503011 | 0.72 | TSHR (0.48) | NPC1MAPTRAB9AAPPSHBG | |
| SCHEMBL15029224 | 0.71 | CA1 (0.44) | NPC1MAPTRAB9ASMN1; SMN2CYP3A4 | |
| SCHEMBL17961713 | 0.70 | TSHR (0.52) | NPC1MAPTRAB9ASHBG | |
| SCHEMBL14828478 | 0.69 | ESR2 (0.61) | MAPTCYP3A4SHBG | |
| SCHEMBL2497844 | 0.69 | SHBG (0.61) | CYP3A4SHBG | |
| SCHEMBL22366368 | 0.68 | APP (0.39) | CYP3A4APP | |
| SCHEMBL10953696 | 0.68 | CYP2A6 (0.42) | NPC1MAPTRAB9AAPPMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944613-B1 | BENZOPYRAN DERIVATIVES | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2002-10-09 | — | — | EP | disclosed |
| US-6153768-A | RECEPTOR BLOCKING ANTIESTROGENS HAVING REDUCED SIDE EFFECTS | C & C RESEARCH LABORATORIES (KR) | 2000-11-28 | — | — | US | disclosed |
| US-5561143-A | ANTICHOLESTEROL AGENTS, ANTILIPEMIC AGENTS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1996-10-01 | — | — | US | disclosed |
| US-5534532-A | ANTICHOLESTEROL AGENTS, SQUALENE SYNTHASE INHIBITOR | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1996-07-09 | — | — | US | disclosed |
| US-5455260-A | Anticholesterol agents; reduction of serum cholesterol without reducing mevalonic metabolite synthesis; side effect | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1995-10-03 | — | — | US | disclosed |
| WO-1994027601-A1 | ALIPHATIC AMINO BIS-ARYL SQUALENE SYNTHASE INHIBITORS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1994-12-08 | — | — | WO | disclosed |