Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.60 |
| ▸ | SRC | P12931 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.54 |
| ▸ | HPGD | P15428 | 7/20 | 0.54 |
| ▸ | MAPT | P10636 | 6/20 | 0.54 |
| ▸ | LMNA | P02545 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.54 |
| ▸ | GCGR | P47871 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.50 |
| ▸ | TUBB | P07437 | 1/20 | 0.50 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.50 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16066037 | 1.00 | ABCG2 (0.60) | ABCG2SRCKDM4EHPGDMAPT | |
| SCHEMBL7592084 | 0.90 | ABCG2 (0.61) | ABCG2SRCMAPTMEN1KMT2A | |
| SCHEMBL7591205 | 0.90 | ABCG2 (0.61) | ABCG2SRCMAPTMEN1KMT2A | |
| SCHEMBL25206045 | 0.85 | KDM4E (0.55) | ABCG2SRCKDM4EHPGDMAPT | |
| SCHEMBL30383583 | 0.85 | KDM4E (0.55) | ABCG2SRCKDM4EHPGDMAPT | |
| SCHEMBL7594011 | 0.85 | KDM4E (0.62) | ABCG2SRCKDM4EHPGDMAPT | |
| SCHEMBL30384051 | 0.84 | KDM4E (0.53) | SRCKDM4EHPGDMAPTLMNA | |
| SCHEMBL19757305 | 0.84 | KDM4E (0.53) | SRCKDM4EHPGDMAPTLMNA | |
| SCHEMBL25193173 | 0.83 | ABCG2 (0.60) | ABCG2HPGDMAPTLMNAMEN1 | |
| SCHEMBL13304210 | 0.82 | GCGR (0.63) | ABCG2SRCKDM4EHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1253141-A1 | Substituted carbazoles as tubulin polymerization inhibitors and their use for the treatment of cancer | Aventis Pharma S.A. (FR) | 2002-10-30 | — | — | EP | disclosed |