Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.61 |
| ▸ | PDE4A | P27815 | 1/20 | 0.60 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.60 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.60 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.53 |
| ▸ | SRC | P12931 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.50 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.49 |
| ▸ | TUBB | P07437 | 1/20 | 0.49 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7591205 | 0.92 | ABCG2 (0.61) | ABCG2PTGER4SRCMAPTABCB1 | |
| SCHEMBL16066037 | 0.90 | ABCG2 (0.60) | ABCG2SRCMAPTABCB1ABCC1 | |
| SCHEMBL7588254 | 0.90 | ABCG2 (0.60) | ABCG2SRCMAPTABCB1ABCC1 | |
| SCHEMBL25193173 | 0.88 | ABCG2 (0.60) | ABCG2MAPTMEN1ALDH1A1MAPK1 | |
| SCHEMBL7594011 | 0.82 | KDM4E (0.62) | ABCG2SRCMAPTABCB1MEN1 | |
| SCHEMBL30274993 | 0.81 | F3 (0.55) | ABCG2PTGER4SRCMAPTMEN1 | |
| SCHEMBL29003694 | 0.81 | F3 (0.55) | ABCG2PTGER4SRCMAPTMEN1 | |
| SCHEMBL7592082 | 0.80 | ABCG2 (0.61) | ABCG2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL25206045 | 0.80 | KDM4E (0.55) | ABCG2SRCMAPTMEN1ALDH1A1 | |
| SCHEMBL30383583 | 0.80 | KDM4E (0.55) | ABCG2SRCMAPTMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1253141-A1 | Substituted carbazoles as tubulin polymerization inhibitors and their use for the treatment of cancer | Aventis Pharma S.A. (FR) | 2002-10-30 | — | — | EP | disclosed |