⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27683385 | 0.77 | — | — | |
| SCHEMBL296265 | 0.69 | — | — | |
| SCHEMBL3305167 | 0.62 | — | — | |
| SCHEMBL10524285 | 0.60 | — | — | |
| SCHEMBL16801438 | 0.60 | — | — | |
| SCHEMBL4156473 | 0.60 | — | — | |
| SCHEMBL13721028 | 0.56 | — | — | |
| SCHEMBL2045252 | 0.55 | — | — | |
| SCHEMBL17734082 | 0.55 | — | — | |
| SCHEMBL2048788 | 0.55 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0805803-B1 | PROCESS FOR THE PRODUCTION OF 1,4,5,6-TETRAHYDROPYRAZINE-2-CARBOXYLIC ACID AMIDES | LONZA AG (CH) | 2002-10-30 | — | — | EP | claimed |
| US-5939549-A | Process for the production of 1,4,5,6-tetrahydropyrazine-2-carboxylic acid amides | LONZA AG (CH) | 1999-08-17 | — | — | US | claimed |
| EP-0813518-B1 | PROCESS FOR PREPARING ALPHA,BETA-DIAMINOACRYLNITRILES | BASF AG (DE) | 1998-12-23 | — | — | EP | claimed |
| EP-0813518-A1 | PROCESS FOR PREPARING ALPHA,BETA-DIAMINOACRYLNITRILES | BASF AKTIENGESELLSCHAFT (DE) | 1997-12-29 | — | — | EP | claimed |
| WO-1997044328-A1 | 1-(ALKANOYL HALIDE)-2-CARBOXAMIDO-1,4,5,6-TETRAHYDROPYRAZINES | BASF AKTIENGESELLSCHAFT (DE) | 1997-11-27 | — | — | WO | claimed |
| EP-0805803-A1 | PROCESS FOR THE PRODUCTION OF 1,4,5,6-TETRAHYDROPYRAZINE-2-CARBOXYLIC ACID AMIDES | LONZA A.G. (CH) | 1997-11-12 | — | — | EP | claimed |
| EP-0799211-A1 | 2-CARBAMOYL-1,4,5,6-TETRAHYDROPYRAZINES | BASF AKTIENGESELLSCHAFT (DE) | 1997-10-08 | — | — | EP | claimed |
| WO-1996027582-A1 | PROCESS FOR PREPARING α,β-DIAMINOACRYLNITRILES | BASF AKTIENGESELLSCHAFT (DE) | 1996-09-12 | — | — | WO | claimed |
| WO-1996022981-A1 | PROCESS FOR THE PRODUCTION OF 1,4,5,6-TETRAHYDROPYRAZINE-2-CARBOXYLIC ACID AMIDES | LONZA AG (CH) | 1996-08-01 | — | — | WO | claimed |
| WO-1996019460-A1 | 2-CARBAMOYL-1,4,5,6-TETRAHYDROPYRAZINES | BASF AKTIENGESELLSCHAFT (DE) | 1996-06-27 | — | — | WO | claimed |
| EP-0175364-A2 | Process for the preparation of alpha-beta-diaminoacrylnitriles | BASF Aktiengesellschaft (DE) | 1986-03-26 | — | — | EP | claimed |
| EP-0805803-B1 | PROCESS FOR THE PRODUCTION OF 1,4,5,6-TETRAHYDROPYRAZINE-2-CARBOXYLIC ACID AMIDES | LONZA AG (CH) | 2002-10-30 | — | — | EP | disclosed |
| EP-0744401-B1 | Process for the preparation of optically active 2-piperazine carboxylic acid derivatives | LONZA AG (CH) | 2001-11-21 | — | — | EP | disclosed |
| EP-1125930-A1 | Optically active piperazine-2-carboxylic acid derivatives and process for their preparation | LONZA AG (CH) | 2001-08-22 | — | — | EP | disclosed |
| US-6111106-A | 1,4,5,6-tetrahydropyrazine-2-carboxamides | LONZA LTD. (CH) | 2000-08-29 | — | — | US | disclosed |
| WO-1996022981-A1 | PROCESS FOR THE PRODUCTION OF 1,4,5,6-TETRAHYDROPYRAZINE-2-CARBOXYLIC ACID AMIDES | LONZA AG (CH) | 1996-08-01 | — | — | WO | disclosed |
| WO-1996019460-A1 | 2-CARBAMOYL-1,4,5,6-TETRAHYDROPYRAZINES | BASF AKTIENGESELLSCHAFT (DE) | 1996-06-27 | — | — | WO | disclosed |
| EP-0175364-B1 | PROCESS FOR THE PREPARATION OF ALPHA-BETA-DIAMINOACRYLNITRILES | BASF Aktiengesellschaft (DE) | 1990-06-06 | — | — | EP | disclosed |
| US-4734499-A | Preparation of α,β-diaminoacrylonitriles | BASF AKTIENGESELLSCHAFT (DE) | 1988-03-29 | — | — | US | disclosed |
| EP-0175364-A2 | Process for the preparation of alpha-beta-diaminoacrylnitriles | BASF Aktiengesellschaft (DE) | 1986-03-26 | — | — | EP | disclosed |