Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.47 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.47 |
| ▸ | CPA3 | P15088 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5054470 | 0.81 | FOLH1 (0.56) | FOLH1GRM3NAALAD2CPA3 | |
| SCHEMBL5059809 | 0.78 | FOLH1 (0.52) | FOLH1GRM3NAALAD2CPA3 | |
| SCHEMBL1373533 | 0.76 | GRM3 (0.55) | FOLH1GRM3 | |
| SCHEMBL5054263 | 0.75 | GRM3 (0.57) | FOLH1GRM3CPA3 | |
| SCHEMBL6037785 | 0.74 | FOLH1 (0.51) | FOLH1GRM3NAALAD2CPA3 | |
| SCHEMBL7607528 | 0.74 | GRM3 (0.52) | FOLH1GRM3 | |
| SCHEMBL8468628 | 0.74 | CPA3 (0.63) | FOLH1GRM3NAALAD2CPA3 | |
| SCHEMBL2368046 | 0.72 | FOLH1 (0.46) | FOLH1GRM3NAALAD2CPA3 | |
| SCHEMBL5053119 | 0.72 | FOLH1 (0.58) | FOLH1GRM3NAALAD2 | |
| SCHEMBL7604506 | 0.72 | FOLH1 (0.55) | FOLH1CPA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066297-B1 | PHOSPHINIC ACID DERIVATIVES | GUILFORD PHARM INC (US) | 2002-10-23 | — | — | EP | disclosed |
| EP-1066297-A1 | PHOSPHINIC ACID DERIVATIVES | GUILFORD PHARMACEUTICALS INC. (US) | 2001-01-10 | — | — | EP | disclosed |
| US-6121252-A | N-ACETYLATED ALPHA-LINKED ACIDIC DIPEPTIDASE (NAALADASE) ENZYME INHIBITORS TO TREAT GLUTAMATE ABNORMALITIES AND PROSTATE DISEASES | GUILFORD PHARMACEUTICALS INC. (US) | 2000-09-19 | — | — | US | disclosed |
| WO-1999050272-A1 | PHOSPHINIC ACID DERIVATIVES | GUILFORD PHARMACEUTICALS INC. (US) | 1999-10-07 | — | — | WO | disclosed |