Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 2/20 | 0.39 |
| ▸ | CES1 | P23141 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9213535 | 0.89 | RYR2 (0.49) | SMN1; SMN2GAARYR2 | |
| SCHEMBL9824427 | 0.81 | CA1 (0.40) | SMN1; SMN2CA12CA1CA2CA9 | |
| SCHEMBL10225789 | 0.79 | MTNR1A (0.51) | GAACA1CA2MTNR1AMTNR1B | |
| SCHEMBL345517 | 0.74 | CA1 (0.56) | GAACA1CA2MTNR1AMTNR1B | |
| SCHEMBL345881 | 0.74 | MTNR1A (0.60) | GAACA1CA2MTNR1AMTNR1B | |
| SCHEMBL345882 | 0.74 | MTNR1A (0.60) | GAACA1CA2MTNR1AMTNR1B | |
| SCHEMBL8603749 | 0.74 | CA1 (0.56) | GAACA1CA2MTNR1AMTNR1B | |
| SCHEMBL8074259 | 0.74 | CA1 (0.56) | GAACA1CA2MTNR1AMTNR1B | |
| SCHEMBL8603880 | 0.74 | MTNR1A (0.60) | GAACA1CA2MTNR1AMTNR1B | |
| SCHEMBL6404425 | 0.73 | RYR2 (0.41) | SMN1; SMN2GAARYR2ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6368573-B1 | MEASURING MYOCARDIAL FUNCTION IN MAMMAL | KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. | 2002-04-09 | — | — | US | disclosed |
| US-5063233-A | Cardiovascular disorders | CIBA-GEIGY CORPORATION (US) | 1991-11-05 | — | — | US | disclosed |
| US-5034381-A | Antagonist | CIBA-GEIGY CORPORATION (US) | 1991-07-23 | — | — | US | disclosed |
| US-4992465-A | Antidepressant, anxiolytic agents; treating central nervous system disorders | CIBA-GEIGY CORPORATION (US) | 1991-02-12 | — | — | US | disclosed |
| US-4968697-A | ADENOSINE-2 RECEPTOR AGONISTS | CIBA-GEIGY CORPORATION (US) | 1990-11-06 | — | — | US | disclosed |
| US-4954504-A | Hypotensive agents, psychotic disorders | CIBA-GEIGY CORPORATION (US) | 1990-09-04 | — | — | US | disclosed |
| EP-0323807-A2 | Certain 2-substituted adenosine derivatives | CIBA-GEIGY AG (CH) | 1989-07-12 | — | — | EP | disclosed |
| US-4801605-A | ANTIDEPRESSANT, NERVOUS SYSTEM DISORDERS, SEROTONIC ANTAGONIST | CIBA-GEIGY CORPORATION (US) | 1989-01-31 | — | — | US | disclosed |
| EP-0277917-A2 | Certain adenosine 5'-carboxamide derivatives | CIBA-GEIGY AG (CH) | 1988-08-10 | — | — | EP | disclosed |
| EP-0267878-A1 | N9-cyclopentyl-substituted adenine derivatives | CIBA-GEIGY AG (CH) | 1988-05-18 | — | — | EP | disclosed |