Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 13/20 | 1.00 |
| ▸ | JAK2 | O60674 | 1/20 | 0.60 |
| ▸ | JAK3 | P52333 | 1/20 | 0.60 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7018359 | 1.00 | LCK (1.00) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7023829 | 0.92 | LCK (0.84) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7592510 | 0.92 | LCK (0.84) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7589881 | 0.91 | LCK (0.83) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7025711 | 0.91 | LCK (0.83) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7028508 | 0.89 | LCK (0.81) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7589479 | 0.89 | LCK (0.81) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7021167 | 0.89 | LCK (0.80) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7592839 | 0.89 | LCK (0.80) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7017781 | 0.88 | LCK (0.79) | LCKJAK2JAK3CYP3A4PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206265-A4 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2002-08-07 | — | — | EP | disclosed |
| EP-1206265-A1 | SRC KINASE INHIBITOR COMPOUNDS | Merck & Co., Inc. (US) | 2002-05-22 | — | — | EP | disclosed |
| WO-2001000213-A1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO., INC. (US) | 2001-01-04 | — | — | WO | disclosed |