Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 2/20 | 0.40 |
| ▸ | UGCG | Q16739 | 2/20 | 0.40 |
| ▸ | GBA2 | Q9HCG7 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6044040 | 1.00 | REN (0.45) | RENKDM4ESMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL6044047 | 1.00 | REN (0.45) | RENKDM4ESMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL6041679 | 0.94 | REN (0.47) | RENKDM4ESMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL6042268 | 0.91 | REN (0.45) | RENKDM4ESMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL6042353 | 0.89 | S1PR5 (0.49) | SMN1; SMN2LMNAKCNH2NPC1RAB9A | |
| SCHEMBL6042358 | 0.89 | S1PR5 (0.49) | SMN1; SMN2LMNAKCNH2NPC1RAB9A | |
| SCHEMBL6042046 | 0.88 | REN (0.45) | RENKDM4ESMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL6042041 | 0.88 | REN (0.45) | RENKDM4ESMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL6043059 | 0.87 | REN (0.57) | RENKDM4ESMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL6043150 | 0.87 | REN (0.51) | RENKDM4ESMN1; SMN2KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002076440-A2 | METHODS OF TREATING ALZHEIMER'S DISEASE WITH PIPERIDIN DERIVATES | ELAN PHARMACEUTICALS, INC. (US) | 2002-10-03 | — | — | WO | disclosed |