Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 19/20 | 0.54 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7597437 | 0.92 | GNRHR (0.50) | GNRHRACHEKCNH2 | |
| SCHEMBL7597708 | 0.91 | GNRHR (0.46) | GNRHRKCNH2 | |
| SCHEMBL7597332 | 0.83 | GNRHR (0.42) | GNRHRKCNH2 | |
| SCHEMBL7591544 | 0.81 | GNRHR (0.43) | GNRHR | |
| SCHEMBL8649918 | 0.80 | GNRHR (0.42) | GNRHR | |
| SCHEMBL7595933 | 0.79 | GNRHR (0.54) | GNRHRACHE | |
| SCHEMBL7595052 | 0.78 | GNRHR (0.54) | GNRHRACHE | |
| SCHEMBL8649469 | 0.77 | GNRHR (0.48) | GNRHRKCNH2 | |
| SCHEMBL7749111 | 0.76 | GNRHR (0.68) | GNRHR | |
| SCHEMBL6704311 | 0.75 | GNRHR (0.36) | GNRHRKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0846119-B1 | THIENOPYRIMIDINE DERIVATIVES, THEIR PRODUCTION AND USE AS ENDOTHELIN ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-11-13 | — | — | EP | disclosed |
| US-6140325-A | HAS ENDOTHELIN ANTAGONISTIC ACTION; FOR TREATING LIVER HYPOFUNCTION, ACUTE RENAL INSUFFICIENCY, CARDIAC INFARCTION OR LIVER INSUFFICIENCY, VASOCONSTRICTION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-10-31 | — | — | US | disclosed |