Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 18/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7597708 | 0.92 | GNRHR (0.46) | GNRHRKCNH2 | |
| SCHEMBL7597437 | 0.91 | GNRHR (0.50) | GNRHRMEN1KMT2AATMKCNH2 | |
| SCHEMBL7593502 | 0.89 | GNRHR (0.45) | GNRHRMEN1KMT2AATMKCNH2 | |
| SCHEMBL7598730 | 0.88 | GNRHR (0.45) | GNRHRMEN1KMT2AATMKCNH2 | |
| SCHEMBL7597198 | 0.84 | NPSR1 (0.37) | GNRHRMEN1KMT2AKCNH2 | |
| SCHEMBL7591971 | 0.83 | GNRHR (0.54) | GNRHRKCNH2 | |
| SCHEMBL8649469 | 0.81 | GNRHR (0.48) | GNRHRKCNH2 | |
| SCHEMBL7595933 | 0.80 | GNRHR (0.54) | GNRHRMEN1KMT2AATM | |
| SCHEMBL7595052 | 0.79 | GNRHR (0.54) | GNRHRMEN1KMT2AATM | |
| SCHEMBL7596246 | 0.77 | MEN1 (0.49) | GNRHRMEN1KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0846119-B1 | THIENOPYRIMIDINE DERIVATIVES, THEIR PRODUCTION AND USE AS ENDOTHELIN ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-11-13 | — | — | EP | disclosed |
| US-6140325-A | HAS ENDOTHELIN ANTAGONISTIC ACTION; FOR TREATING LIVER HYPOFUNCTION, ACUTE RENAL INSUFFICIENCY, CARDIAC INFARCTION OR LIVER INSUFFICIENCY, VASOCONSTRICTION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-10-31 | — | — | US | disclosed |