Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 11/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 9/20 | 0.42 |
| ▸ | ITGB8 | P26012 | 6/20 | 0.42 |
| ▸ | ITGB6 | P18564 | 5/20 | 0.42 |
| ▸ | ITGA5 | P08648 | 4/20 | 0.42 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7596462 | 1.00 | ITGAV (0.42) | ITGAVITGB3ITGB8ITGB6ITGA5 | |
| SCHEMBL7589610 | 0.88 | ITGAV (0.47) | ITGAVITGB3ITGB8ITGB6ITGA5 | |
| SCHEMBL7591361 | 0.88 | ITGAV (0.47) | ITGAVITGB3ITGB8ITGB6ITGA5 | |
| SCHEMBL4045463 | 0.86 | ITGB3 (0.50) | ITGAVITGB3ITGA2B | |
| SCHEMBL7596273 | 0.84 | ITGAV (0.48) | ITGAVITGB3ITGB8ITGB6ITGA5 | |
| SCHEMBL7597763 | 0.84 | ITGAV (0.48) | ITGAVITGB3ITGB8ITGB6ITGA5 | |
| SCHEMBL7595601 | 0.84 | ITGAV (0.49) | ITGAVITGB3ITGB8ITGB6ITGA5 | |
| SCHEMBL7591574 | 0.84 | ITGAV (0.49) | ITGAVITGB3ITGB8ITGB6ITGA5 | |
| SCHEMBL7561021 | 0.84 | ITGAV (0.47) | ITGAVITGB3ITGB8ITGB6ITGA5 | |
| SCHEMBL7592541 | 0.84 | ITGAV (0.47) | ITGAVITGB3ITGB8ITGB6ITGA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140792-A1 | 3,4-DIAMINO-3-CYCLOBUTENE-1,2-DIONE DERIVATIVES WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035855-A1 | 3,4-DIAMINO-3-CYCLOBUTENE-1,2-DIONE DERIVATIVES WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-06-22 | — | — | WO | disclosed |