Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 8/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 8/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 8/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 3/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7122322 | 1.00 | CHRNB2 (0.39) | CHRNB2CHRNA7CHRNA4ACKR3HRH3 | |
| SCHEMBL7118130 | 0.90 | CHRNB2 (0.36) | CHRNB2CHRNA7CHRNA4ACKR3 | |
| SCHEMBL7130636 | 0.90 | CHRNB2 (0.39) | CHRNB2CHRNA7CHRNA4HRH3SMN1; SMN2 | |
| SCHEMBL7125523 | 0.90 | CHRNA7 (0.39) | CHRNB2CHRNA7CHRNA4KCNH2 | |
| SCHEMBL7129413 | 0.90 | CHRNB2 (0.39) | CHRNB2CHRNA7CHRNA4ACKR3KCNH2 | |
| SCHEMBL7225803 | 0.89 | CHRNB2 (0.41) | CHRNB2CHRNA7CHRNA4ACKR3HRH3 | |
| SCHEMBL7124809 | 0.87 | ACKR3 (0.43) | CHRNB2CHRNA7CHRNA4ACKR3KCNH2 | |
| SCHEMBL7118349 | 0.87 | CHRNB2 (0.39) | CHRNB2CHRNA7CHRNA4ACKR3HRH3 | |
| SCHEMBL7220190 | 0.86 | CHRNA7 (0.40) | CHRNB2CHRNA7CHRNA4HRH3KCNH2 | |
| SCHEMBL6881256 | 0.85 | CHRNB2 (0.42) | CHRNB2CHRNA7CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002015662-A2 | QUINUCLIDINE-SUBSTITUTED HETEROARYL MOIETIES FOR TREATMENT OF DISEASE (NICOTINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS | PHARMACIA & UPJOHN COMPANY (US) | 2002-02-28 | — | — | WO | claimed |