Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 19/20 | 0.69 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | JAK3 | P52333 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7591342 | 0.95 | LCK (0.69) | LCKJAK2JAK3 | |
| SCHEMBL7021396 | 0.84 | LCK (0.80) | LCKJAK2JAK3 | |
| SCHEMBL7587010 | 0.83 | LCK (0.61) | LCKJAK2JAK3 | |
| SCHEMBL7016363 | 0.82 | LCK (0.74) | LCKJAK2JAK3 | |
| SCHEMBL7021615 | 0.82 | LCK (1.00) | LCKJAK2JAK3 | |
| SCHEMBL7105662 | 0.81 | LCK (0.88) | LCKJAK2JAK3 | |
| SCHEMBL7016429 | 0.81 | LCK (0.85) | LCKJAK2JAK3 | |
| SCHEMBL7017426 | 0.80 | LCK (0.71) | LCKJAK2JAK3 | |
| SCHEMBL7022428 | 0.78 | LCK (0.78) | LCKJAK2JAK3 | |
| SCHEMBL7585633 | 0.77 | LCK (1.00) | LCKJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206265-A4 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2002-08-07 | — | — | EP | disclosed |
| EP-1206265-A1 | SRC KINASE INHIBITOR COMPOUNDS | Merck & Co., Inc. (US) | 2002-05-22 | — | — | EP | disclosed |
| WO-2001000213-A1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO., INC. (US) | 2001-01-04 | — | — | WO | disclosed |