Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 14/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MMP12 | P39900 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | EDNRB | P24530 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8193067 | 0.92 | GNRHR (0.36) | GNRHRKCNH2KMT2AMMP2MMP9 | |
| SCHEMBL7593195 | 0.92 | GNRHR (0.37) | GNRHRKCNH2MEN1KMT2AALDH1A1 | |
| SCHEMBL7592912 | 0.92 | GNRHR (0.37) | GNRHRKCNH2MEN1KMT2AALDH1A1 | |
| SCHEMBL7591509 | 0.90 | GNRHR (0.37) | GNRHRMEN1KMT2AALDH1A1EDNRB | |
| SCHEMBL7598751 | 0.90 | GNRHR (0.36) | GNRHRKCNH2MEN1KMT2AALDH1A1 | |
| SCHEMBL7594085 | 0.90 | GNRHR (0.36) | GNRHRMEN1KMT2AALDH1A1EDNRB | |
| SCHEMBL7591456 | 0.87 | GNRHR (0.36) | GNRHRMEN1KMT2AALDH1A1EDNRB | |
| SCHEMBL7593503 | 0.86 | GNRHR (0.33) | GNRHRKCNH2EDNRB | |
| SCHEMBL7596779 | 0.85 | GNRHR (0.43) | GNRHRMEN1KMT2AMMP2MMP9 | |
| SCHEMBL7594585 | 0.85 | GNRHR (0.41) | GNRHRMEN1KMT2AALDH1A1EDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0846119-B1 | THIENOPYRIMIDINE DERIVATIVES, THEIR PRODUCTION AND USE AS ENDOTHELIN ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-11-13 | — | — | EP | disclosed |
| US-6140325-A | HAS ENDOTHELIN ANTAGONISTIC ACTION; FOR TREATING LIVER HYPOFUNCTION, ACUTE RENAL INSUFFICIENCY, CARDIAC INFARCTION OR LIVER INSUFFICIENCY, VASOCONSTRICTION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-10-31 | — | — | US | disclosed |