Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 19/20 | 0.55 |
| ▸ | MMP2 | P08253 | 12/20 | 0.55 |
| ▸ | MMP3 | P08254 | 12/20 | 0.55 |
| ▸ | MMP9 | P14780 | 8/20 | 0.54 |
| ▸ | MMP7 | P09237 | 7/20 | 0.54 |
| ▸ | MMP14 | P50281 | 4/20 | 0.54 |
| ▸ | MMP8 | P22894 | 5/20 | 0.52 |
| ▸ | FCER2 | P06734 | 2/20 | 0.52 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.50 |
| ▸ | MMP12 | P39900 | 1/20 | 0.50 |
| ▸ | MMP13 | P45452 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7593715 | 0.94 | MMP1 (0.57) | MMP1MMP2MMP3MMP9MMP7 | |
| SCHEMBL7591565 | 0.90 | MMP1 (0.57) | MMP1MMP2MMP3MMP9MMP7 | |
| SCHEMBL7397714 | 0.87 | MMP1 (0.55) | MMP1MMP2MMP3MMP9MMP7 | |
| SCHEMBL6416229 | 0.85 | MMP1 (0.56) | MMP1MMP2MMP3MMP9MMP7 | |
| SCHEMBL6846260 | 0.85 | MMP1 (0.56) | MMP1MMP2MMP3MMP9MMP7 | |
| SCHEMBL7383987 | 0.85 | MMP1 (0.56) | MMP1MMP2MMP3MMP9MMP7 | |
| SCHEMBL7424545 | 0.85 | MMP1 (0.56) | MMP1MMP2MMP3MMP9MMP7 | |
| SCHEMBL7283831 | 0.85 | MMP1 (0.71) | MMP1MMP2MMP3MMP9MMP7 | |
| SCHEMBL7283858 | 0.85 | MMP1 (0.71) | MMP1MMP2MMP3MMP9MMP7 | |
| SCHEMBL7895353 | 0.85 | MMP1 (0.55) | MMP1MMP2MMP3MMP9MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0826000-B1 | PEPTIDE COMPOUNDS WHICH INHIBIT METALLOPROTEINASE AND TNF LIBERATION AND THEIR THERAPEUTIC USES | DARWIN DISCOVERY LTD (GB) | 2002-10-23 | — | — | EP | disclosed |
| US-6110896-A | TRIPEPTIDYL DERIVATIVES HAVING A MERCAPTO OR ACYLTHIO GROUP AND WHICH ARE AMIDES; UTILITY AS MATRIX METALLOPROTEASE OR TNF INHIBITORS | DARWIN DISCOVERY, LTD. (GB) | 2000-08-29 | — | — | US | disclosed |