Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 8/20 | 0.54 |
| ▸ | ITGAV | P06756 | 5/20 | 0.54 |
| ▸ | MMP9 | P14780 | 10/20 | 0.44 |
| ▸ | MMP2 | P08253 | 10/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.41 |
| ▸ | MMP8 | P22894 | 3/20 | 0.39 |
| ▸ | MMP13 | P45452 | 2/20 | 0.39 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.39 |
| ▸ | MMP12 | P39900 | 2/20 | 0.39 |
| ▸ | MMP14 | P50281 | 2/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MMP7 | P09237 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7594982 | 0.84 | ITGAV (0.53) | ITGB3ITGAV | |
| Trifluoroacetic Acid SCHEMBL7590565 | 0.83 | ITGB3 (0.38) | ITGB3ITGAVMMP9MMP2ITGA2B | |
| Trifluoroacetic Acid SCHEMBL7590553 | 0.83 | ITGB3 (0.52) | ITGB3ITGAVITGA2B | |
| SCHEMBL7596227 | 0.82 | ITGAV (0.54) | ITGB3ITGAVITGA2B | |
| SCHEMBL7591676 | 0.81 | ITGAV (0.39) | ITGB3ITGAV | |
| SCHEMBL7596670 | 0.80 | ITGAV (0.55) | ITGB3ITGAV | |
| SCHEMBL7591941 | 0.80 | ITGB3 (0.55) | ITGB3ITGAVITGA2B | |
| SCHEMBL6422836 | 0.70 | ITGAV (1.00) | ITGB3ITGAVITGA2B | |
| SCHEMBL6420967 | 0.70 | ITGAV (1.00) | ITGB3ITGAVITGA2B | |
| SCHEMBL6421699 | 0.70 | ITGAV (1.00) | ITGB3ITGAVITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1040098-A1 | INTEGRIN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (a New Jersey corp.) (US) | 2000-10-04 | — | — | EP | disclosed |
| WO-1999031061-A1 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1999-06-24 | — | — | WO | disclosed |