Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 12/20 | 0.51 |
| ▸ | MMP2 | P08253 | 11/20 | 0.51 |
| ▸ | MMP13 | P45452 | 6/20 | 0.51 |
| ▸ | MMP1 | P03956 | 5/20 | 0.51 |
| ▸ | MMP8 | P22894 | 3/20 | 0.51 |
| ▸ | MMP3 | P08254 | 2/20 | 0.51 |
| ▸ | MMP7 | P09237 | 2/20 | 0.51 |
| ▸ | MMP14 | P50281 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7425774 | 0.93 | MMP9 (0.51) | MMP9MMP2MMP13MMP1MMP8 | |
| SCHEMBL7595945 | 0.93 | MMP9 (0.51) | MMP9MMP2MMP13MMP1MMP8 | |
| SCHEMBL7594377 | 0.90 | MMP9 (0.66) | MMP9MMP2MMP13MMP1MMP8 | |
| SCHEMBL7599171 | 0.90 | MMP9 (0.66) | MMP9MMP2MMP13MMP1MMP8 | |
| SCHEMBL7593379 | 0.90 | MMP9 (0.54) | MMP9MMP2MMP13MMP1MMP8 | |
| SCHEMBL7593771 | 0.90 | MMP9 (0.66) | MMP9MMP2MMP13MMP1MMP8 | |
| SCHEMBL7594722 | 0.90 | MMP9 (0.66) | MMP9MMP2MMP13MMP1MMP8 | |
| SCHEMBL7429125 | 0.90 | MMP9 (0.66) | MMP9MMP2MMP13MMP1MMP8 | |
| SCHEMBL7595406 | 0.89 | MMP9 (0.47) | MMP9MMP2MMP13MMP1MMP8 | |
| SCHEMBL7594938 | 0.79 | MMP9 (0.67) | MMP9MMP2MMP13MMP1MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147101-B1 | REVERSE HYDROXAMATE INHIBITORS OF MATRIX METALLOPROTEINASES | ABBOTT LAB (US) | 2002-11-20 | — | — | EP | claimed |
| EP-1147101-B1 | REVERSE HYDROXAMATE INHIBITORS OF MATRIX METALLOPROTEINASES | ABBOTT LAB (US) | 2002-11-20 | — | — | EP | disclosed |
| US-6294573-B1 | FOR THERAPY RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPENIAS SUCH AS OSTEOPOROSIS, PERIODONTITIS, GINGIVITIS, CORNEAL, EPIDERMAL OR GASTRIC ULCERATION, AND TUMOR GROWTH AND METASTASIS OR INVASION | ABBOTT LABORATORIES | 2001-09-25 | — | — | US | disclosed |