Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 14/20 | 0.48 |
| ▸ | CCR3 | P51677 | 14/20 | 0.47 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.39 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.38 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7596980 | 0.83 | HRH1 (0.47) | HRH1CCR3FPR2PROKR1KCNH2 | |
| SCHEMBL6403204 | 0.80 | CCR3 (0.53) | HRH1CCR3FPR2PROKR1KCNH2 | |
| SCHEMBL6397458 | 0.79 | HRH1 (0.52) | HRH1CCR3FPR2PROKR1KCNH2 | |
| SCHEMBL6404026 | 0.78 | CCR3 (0.52) | HRH1CCR3FPR2PROKR1KCNH2 | |
| SCHEMBL7598716 | 0.78 | HRH1 (0.49) | HRH1CCR3FPR2PROKR1KCNH2 | |
| SCHEMBL7601251 | 0.78 | HRH1 (0.54) | HRH1CCR3FPR2PROKR1KCNH2 | |
| SCHEMBL6398700 | 0.78 | HRH1 (0.49) | HRH1CCR3FPR2PROKR1KCNH2 | |
| SCHEMBL6398460 | 0.77 | CCR3 (0.54) | HRH1CCR3KCNH2KDM4ECARM1 | |
| SCHEMBL6398399 | 0.76 | CCR3 (0.56) | HRH1CCR3FPR2PROKR1KCNH2 | |
| SCHEMBL6402106 | 0.76 | CCR3 (0.47) | HRH1CCR3FPR2PROKR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165545-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000058305-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2000-10-05 | — | — | WO | disclosed |