Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 5/20 | 0.47 |
| ▸ | ACHE | P22303 | 11/20 | 0.46 |
| ▸ | BACE1 | P56817 | 8/20 | 0.46 |
| ▸ | CCR3 | P51677 | 5/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7601251 | 0.94 | HRH1 (0.54) | HRH1ACHEBACE1CCR3KCNH2 | |
| SCHEMBL6394743 | 0.88 | CCR3 (0.47) | HRH1CCR3KCNH2KDM4EFPR2 | |
| SCHEMBL7596643 | 0.83 | HRH1 (0.48) | HRH1CCR3KCNH2KDM4EFPR2 | |
| SCHEMBL6402826 | 0.83 | HRH1 (0.49) | HRH1CCR3KCNH2KDM4EFPR2 | |
| SCHEMBL6398460 | 0.83 | CCR3 (0.54) | HRH1CCR3KCNH2KDM4E | |
| SCHEMBL6397083 | 0.83 | HRH1 (0.53) | HRH1CCR3KCNH2KDM4EFPR2 | |
| SCHEMBL6396292 | 0.83 | HRH1 (0.53) | HRH1CCR3KCNH2KDM4EFPR2 | |
| SCHEMBL6396116 | 0.81 | HRH1 (0.47) | HRH1CCR3KCNH2KDM4EFPR2 | |
| SCHEMBL6396396 | 0.79 | CCR3 (0.46) | HRH1CCR3KCNH2KDM4EFPR2 | |
| SCHEMBL6402106 | 0.79 | CCR3 (0.47) | HRH1CCR3KCNH2KDM4EFPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002540204-A | — | — | 2002-11-26 | — | — | JP | claimed |
| EP-1165545-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2002-01-02 | — | — | EP | claimed |
| WO-2000058305-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2000-10-05 | — | — | WO | claimed |