Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | DRD5 | P21918 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | PRCP | P42785 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6253578 | 0.90 | SLC6A2 (0.51) | SLC6A2SLC6A4SLC6A3DRD1DRD2 | |
| SCHEMBL5244479 | 0.84 | CA1 (0.55) | DRD1DRD2DRD4CA1CA2 | |
| SCHEMBL7592205 | 0.81 | PRCP (0.62) | SLC6A2SLC6A4SLC6A3DRD1DRD2 | |
| SCHEMBL16280607 | 0.81 | DRD2 (0.45) | DRD1DRD2CA1CA2CA9 | |
| SCHEMBL5245716 | 0.80 | KDM4E (0.51) | MAPTDRD1DRD2CA1CA2 | |
| SCHEMBL28942533 | 0.80 | PRCP (0.64) | SLC6A2SLC6A4SLC6A3DRD1DRD2 | |
| SCHEMBL29783557 | 0.80 | PRCP (0.64) | SLC6A2SLC6A4SLC6A3DRD1DRD2 | |
| SCHEMBL5244484 | 0.79 | SMN1; SMN2 (0.52) | DRD1DRD2CA1CA2CA9 | |
| SCHEMBL4467003 | 0.76 | SLC6A2 (0.45) | SLC6A2SLC6A4SLC6A3DRD1DRD2 | |
| SCHEMBL14354453 | 0.76 | SLC6A2 (0.55) | SLC6A2SLC6A4SLC6A3DRD1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246805-A1 | 4-PHENYL-SUBSTITUTED TETRAHYDROISOQUINOLINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE AND SEROTONIN | ALBANY MOLECULAR RESEARCH, INC. (US) | 2002-10-09 | — | — | EP | claimed |
| WO-2001032624-A1 | 4-PHENYL-SUBSTITUTED TETRAHYDROISOQUINOLINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE AND SEROTONIN | DU PONT PHARMACEUTICALS COMPANY (US) | 2001-05-10 | — | — | WO | claimed |