Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 17/20 | 0.67 |
| ▸ | EDNRB | P24530 | 15/20 | 0.67 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.63 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.63 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.63 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.63 |
| ▸ | DHPS | P49366 | 1/20 | 0.63 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.63 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7598296 | 0.91 | EDNRA (0.79) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL8397142 | 0.90 | EDNRA (0.70) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL7602383 | 0.88 | EDNRB (0.61) | EDNRAEDNRB | |
| SCHEMBL7597077 | 0.86 | EDNRA (0.60) | EDNRAEDNRB | |
| SCHEMBL8399578 | 0.84 | EDNRA (0.66) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL7600949 | 0.83 | EDNRA (0.79) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL7582530 | 0.80 | EDNRA (0.84) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL2722254 | 0.80 | EDNRA (0.81) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL7818379 | 0.80 | EDNRA (0.76) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL2440965 | 0.80 | EDNRA (0.77) | EDNRAEDNRBABCC3ABCC4NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0768304-B1 | N-(Pyrimidinyl)-benzenesulfonamides as medicaments | HOFFMANN LA ROCHE (CH) | 2002-05-22 | — | — | EP | disclosed |
| EP-0768304-A1 | N-(Pyrimidinyl)-benzenesulfonamides as medicaments | F. HOFFMANN-LA ROCHE AG (CH) | 1997-04-16 | — | — | EP | disclosed |