Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.52 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 8/20 | 0.45 |
| ▸ | PPARG | P37231 | 7/20 | 0.45 |
| ▸ | PPARD | Q03181 | 7/20 | 0.45 |
| ▸ | PPARA | Q07869 | 7/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | TLR2 | O60603 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | FABP4 | P15090 | 2/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.45 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.45 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1161964 | 0.88 | TSHR (0.61) | TSHRAKR1B1GPR84PPARGPPARD | |
| SCHEMBL3630253 | 0.81 | DGKA (0.54) | TSHRAKR1B1GPR84PPARGPPARD | |
| SCHEMBL246949 | 0.81 | PHF8 (0.48) | TSHRSLC22A6OR51E2LMNA | |
| SCHEMBL5503309 | 0.80 | TSHR (0.57) | TSHRALDH1A1MEN1KMT2ALMNA | |
| Alcohol SCHEMBL11785193 | 0.79 | TSHR (0.75) | TSHRAKR1B1GPR84PPARGPPARD | |
| SCHEMBL23754644 | 0.79 | DGKA (0.57) | TSHRGPR84PPARGPPARDPPARA | |
| SCHEMBL8393818 | 0.79 | DGKA (0.57) | TSHRGPR84PPARGPPARDPPARA | |
| SCHEMBL5855334 | 0.79 | DGKA (0.57) | TSHRGPR84PPARGPPARDPPARA | |
| SCHEMBL10411539 | 0.79 | DGKA (0.52) | TSHRAKR1B1GPR84PPARGPPARD | |
| SCHEMBL8128698 | 0.79 | DGKA (0.57) | TSHRGPR84PPARGPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020004548-A1 | SYNTHESIS OF MATTE BEADS CONTAINING CARBOXYLIC ACID AND THEIR USE IN PHOTOGRAPHIC ELEMENTS | SMITH DENNIS EDWARD (US) | 2002-01-10 | — | — | US | disclosed |
| EP-0831366-A1 | Synthesis of matte beads containing a carboxylic acid monomer and their use in photographic elements | EASTMAN KODAK COMPANY (US) | 1998-03-25 | — | — | EP | disclosed |