Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 5/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6703239 | 0.84 | AAK1 (0.40) | AAK1CTSSCTSKATML3MBTL1 | |
| SCHEMBL22928454 | 0.82 | KMT2A (0.55) | MMEHTTKMT2AMEN1ALDH1A1 | |
| SCHEMBL127388 | 0.80 | ATM (0.44) | AAK1CTSSCTSKATML3MBTL1 | |
| SCHEMBL13059481 | 0.80 | ATM (0.44) | AAK1CTSSCTSKATML3MBTL1 | |
| SCHEMBL27342092 | 0.79 | ATM (0.42) | MMEAAK1CTSSCTSKATM | |
| SCHEMBL27331415 | 0.79 | ATM (0.42) | MMEAAK1CTSSCTSKATM | |
| SCHEMBL1916161 | 0.77 | MME (0.43) | MMECTSSCTSKL3MBTL1HTT | |
| SCHEMBL1915606 | 0.77 | MME (0.43) | MMECTSSCTSKL3MBTL1HTT | |
| SCHEMBL1915282 | 0.77 | MME (0.43) | MMECTSSCTSKL3MBTL1HTT | |
| SCHEMBL7067828 | 0.77 | MME (0.43) | MMECTSSCTSKL3MBTL1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1257535-A1 | SUBSTITUTED PYRIDINE COMPOUNDS USEFUL FOR CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LABORATORIES (US) | 2002-11-20 | — | — | EP | disclosed |
| WO-2001056991-A1 | SUBSTITUTED PYRIDINE COMPOUNDS USEFUL FOR CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LABORATORIES (US) | 2001-08-09 | — | — | WO | disclosed |