Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7596777 | 0.84 | HTT (0.41) | SMN1; SMN2LMNAHTTMAPK14POLB | |
| SCHEMBL7599929 | 0.84 | TP53 (0.39) | SMN1; SMN2KMT2AHPGDMEN1 | |
| SCHEMBL6770164 | 0.82 | SMN1; SMN2 (0.48) | SMN1; SMN2RAB9ANPC1KMT2ALMNA | |
| SCHEMBL7596873 | 0.81 | HPGD (0.44) | SMN1; SMN2RAB9ANPC1KMT2ALMNA | |
| SCHEMBL7600206 | 0.81 | PDK2 (0.39) | LMNA | |
| SCHEMBL7596505 | 0.80 | POLB (0.41) | SMN1; SMN2RAB9ANPC1KMT2ALMNA | |
| SCHEMBL7595652 | 0.79 | PDK2 (0.41) | L3MBTL1 | |
| SCHEMBL7596021 | 0.78 | HDAC1 (0.45) | RAB9ANPC1KMT2AHTTHPGD | |
| SCHEMBL7599607 | 0.78 | NPC1 (0.46) | RAB9ANPC1KMT2ALMNAHTT | |
| SCHEMBL7599983 | 0.78 | PDK2 (0.37) | SMN1; SMN2RAB9AKMT2AHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255736-A2 | SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | Boehringer Ingelheim Pharma KG (DE) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001047898-A2 | SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-07-05 | — | — | WO | disclosed |