Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 7/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7600360 | 0.88 | LMNA (0.38) | PDK2ALDH1A1MAPTITGA4SMN1; SMN2 | |
| SCHEMBL7600206 | 0.86 | PDK2 (0.39) | PDK2 | |
| SCHEMBL7595652 | 0.84 | PDK2 (0.41) | PDK2 | |
| SCHEMBL7597632 | 0.84 | ALDH1A1 (0.44) | PDK2ALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL7600948 | 0.83 | MTTP (0.43) | PDK2 | |
| SCHEMBL7612764 | 0.82 | MAPT (0.38) | PDK2ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL7599929 | 0.82 | TP53 (0.39) | MEN1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL7596692 | 0.81 | MTTP (0.36) | PDK2 | |
| SCHEMBL7596021 | 0.81 | HDAC1 (0.45) | ALDH1A1MEN1KMT2ANPSR1HPGD | |
| SCHEMBL7599607 | 0.81 | NPC1 (0.46) | ALDH1A1MAPTMEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255736-A2 | SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | Boehringer Ingelheim Pharma KG (DE) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001047898-A2 | SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-07-05 | — | — | WO | disclosed |