Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | STAT3 | P40763 | 2/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16213017 | 0.84 | STAT3 (0.46) | KMT2AALDH1A1MEN1STAT3TDP1 | |
| SCHEMBL16213015 | 0.84 | STAT3 (0.46) | KMT2AALDH1A1MEN1STAT3TDP1 | |
| SCHEMBL16213013 | 0.84 | STAT3 (0.46) | KMT2AALDH1A1MEN1STAT3TDP1 | |
| SCHEMBL5173535 | 0.84 | STAT3 (0.39) | KMT2AALDH1A1MEN1STAT3P2RX7 | |
| SCHEMBL17498070 | 0.81 | STAT3 (0.48) | KMT2AALDH1A1MEN1STAT3TDP1 | |
| SCHEMBL16583135 | 0.81 | STAT3 (0.45) | KMT2AALDH1A1MEN1STAT3MMP13 | |
| SCHEMBL17498067 | 0.81 | STAT3 (0.48) | KMT2AALDH1A1MEN1STAT3TDP1 | |
| SCHEMBL27997551 | 0.81 | STAT3 (0.48) | KMT2AALDH1A1MEN1STAT3TDP1 | |
| SCHEMBL2545093 | 0.80 | CA2 (0.47) | KMT2AALDH1A1MEN1STAT3P2RX7 | |
| SCHEMBL2545096 | 0.80 | CA2 (0.47) | KMT2AALDH1A1MEN1STAT3P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1257535-A1 | SUBSTITUTED PYRIDINE COMPOUNDS USEFUL FOR CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LABORATORIES (US) | 2002-11-20 | — | — | EP | disclosed |
| WO-2001056991-A1 | SUBSTITUTED PYRIDINE COMPOUNDS USEFUL FOR CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LABORATORIES (US) | 2001-08-09 | — | — | WO | disclosed |