Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 18/20 | 0.60 |
| ▸ | PRSS1 | P07477 | 10/20 | 0.60 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.57 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.57 |
| ▸ | F2 | P00734 | 4/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7600818 | 0.91 | F10 (0.56) | F10PRSS1PRSS2PRSS3F2 | |
| SCHEMBL7450111 | 0.91 | F10 (0.72) | F10PRSS1PRSS2PRSS3F2 | |
| Trifluoroacetic Acid SCHEMBL7120279 | 0.85 | F10 (0.67) | F10PRSS1PRSS2PRSS3F2 | |
| SCHEMBL7452309 | 0.85 | F10 (0.64) | F10PRSS1PRSS2PRSS3F2 | |
| Trifluoroacetic Acid SCHEMBL7598687 | 0.83 | PRSS1 (0.58) | F10PRSS1PRSS2PRSS3F2 | |
| SCHEMBL7600977 | 0.82 | F10 (0.58) | F10PRSS1PRSS2PRSS3F2 | |
| SCHEMBL6303962 | 0.82 | F10 (0.60) | F10PRSS1PRSS2PRSS3F2 | |
| SCHEMBL7594804 | 0.80 | F10 (0.64) | F10PRSS1PRSS2PRSS3F2 | |
| SCHEMBL7600944 | 0.79 | F10 (0.49) | F10PRSS1PRSS2PRSS3F2 | |
| SCHEMBL7600388 | 0.78 | TSHR (0.54) | F10PRSS1PRSS2PRSS3F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1257530-A1 | AMINOSULFONYLBIPHENYL DERIVATIVES | MERCK PATENT GmbH (DE) | 2002-11-20 | — | — | EP | disclosed |
| WO-2001062717-A1 | AMINOSULFONYLBIPHENYL DERIVATIVES | MERCK PATENT GMBH (DE) | 2001-08-30 | — | — | WO | disclosed |