Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 11/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 4/20 | 0.43 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL7113085 | 0.90 | F10 (0.56) | F10PRSS1F2PRSS2PRSS3 | |
| Trifluoroacetic Acid SCHEMBL7598687 | 0.85 | PRSS1 (0.58) | F10PRSS1F2PRSS2PRSS3 | |
| SCHEMBL6303962 | 0.81 | F10 (0.60) | F10PRSS1F2PRSS2PRSS3 | |
| SCHEMBL7450111 | 0.79 | F10 (0.72) | F10PRSS1F2PRSS2PRSS3 | |
| SCHEMBL6296864 | 0.79 | ALDH1A1 (0.45) | ALDH1A1HPGDGSTO1GAAMAPT | |
| SCHEMBL7599290 | 0.79 | F10 (0.60) | F10PRSS1F2PRSS2PRSS3 | |
| Trifluoroacetic Acid SCHEMBL7120279 | 0.78 | F10 (0.67) | F10PRSS1F2PRSS2PRSS3 | |
| SCHEMBL7086229 | 0.77 | KMT2A (0.55) | ALDH1A1GAAMAPT | |
| SCHEMBL6303566 | 0.75 | F10 (0.58) | F10PRSS1F2PRSS2PRSS3 | |
| SCHEMBL7059244 | 0.75 | PRSS1 (0.51) | F10PRSS1F2PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1257530-A1 | AMINOSULFONYLBIPHENYL DERIVATIVES | MERCK PATENT GmbH (DE) | 2002-11-20 | — | — | EP | disclosed |
| WO-2001062717-A1 | AMINOSULFONYLBIPHENYL DERIVATIVES | MERCK PATENT GMBH (DE) | 2001-08-30 | — | — | WO | disclosed |