Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | ESR1 | P03372 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.57 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | GRK5 | P34947 | 1/20 | 0.44 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.44 |
| ▸ | PRKX | P51817 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7594842 | 0.86 | ALDH1A1 (0.54) | ALDH1A1ESR1CYP3A4ESR2MAPK14 | |
| SCHEMBL7594540 | 0.85 | ALDH1A1 (0.47) | ALDH1A1ESR1CYP3A4ESR2CHEK1 | |
| SCHEMBL7596217 | 0.85 | ALDH1A1 (0.52) | ALDH1A1ESR1CYP3A4ESR2MAPK14 | |
| SCHEMBL28205576 | 0.83 | ALDH1A1 (0.60) | ALDH1A1ESR1CYP3A4ESR2NR4A2 | |
| SCHEMBL6440668 | 0.79 | CYSLTR1 (0.67) | FFAR1CYSLTR2CYSLTR1AKR1B1 | |
| SCHEMBL30538032 | 0.79 | CYSLTR1 (0.67) | FFAR1CYSLTR2CYSLTR1AKR1B1 | |
| SCHEMBL7595880 | 0.79 | ALDH1A1 (0.46) | ALDH1A1ESR1CYP3A4ESR2MAPK14 | |
| SCHEMBL3048632 | 0.78 | CYSLTR1 (0.66) | FFAR1CYSLTR2CYSLTR1AKR1B1 | |
| SCHEMBL3048640 | 0.78 | CYSLTR1 (0.66) | FFAR1CYSLTR2CYSLTR1AKR1B1 | |
| SCHEMBL7595258 | 0.78 | CYSLTR1 (0.66) | FFAR1CYSLTR2CYSLTR1AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0862557-B1 | SYMMETRICAL bis-HETEROARYLMETHOXYPHENYLALKYL CARBOXYLATES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LAB (US) | 2002-11-27 | — | — | EP | disclosed |
| US-5843968-A | Symmetrical bis-heteroarylmethoxy-phenylalkyl carboxylates as inhibitors of leukotriene biosynthesis | ABBOTT LABORATORIES (US) | 1998-12-01 | — | — | US | disclosed |
| US-5795900-A | Symmetrical bis-heteroaryl-methoxy-phenylalkyl carboxylates as inhibitors of leukotriene biosynthesis | ABBOTT LABORATORIES (US) | 1998-08-18 | — | — | US | disclosed |